Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol.
Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol.
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DOI：
10.1186/1866-1955-4-18
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发表时间：
2012-07-03
影响因子：
4.9
通讯作者：
Granato A
中科院分区：
文献类型：
--
作者：
De Giorgio A;Comparini SE;Intra FS;Granato A
子宫内接触酒精是导致智力低下的已知原因。尽管一定程度的运动障碍总是与胎儿酒精谱系障碍相关，但人们对运动控制缺陷的神经生物学基础知之甚少。我们在胎儿酒精谱系障碍大鼠模型中研究了含有小白蛋白的纹状体中间神经元。新生大鼠从出生后第二天到第六天通过吸入乙醇，并在出生后第 60 天通过免疫组织化学标记小清蛋白纹状体神经元。使用 Voronoi 空间镶嵌研究小清蛋白中间神经元的空间分布，并完全重建了它们的树突树。乙醇处理的动物的小白蛋白中间神经元表现出与对照动物中观察到的相似的聚集空间分布。与对照组相比，乙醇处理的动物中小清蛋白中间神经元的树突树显着减少。纹状体小白蛋白中间神经元是服务于运动控制的大脑网络的重要组成部分。因此，树突的收缩可能导致胎儿酒精谱系障碍中观察到的运动和认知症状。
Exposure to alcohol in utero is a known cause of mental retardation. Although a certain degree of motor impairment is always associated with fetal alcohol spectrum disorder, little is known about the neurobiological basis of the defective motor control. We have studied the striatal interneurons containing parvalbumin in a rat model of fetal alcohol spectrum disorder. Newborn rats received ethanol by inhalation from postnatal day two through six and parvalbumin striatal neurons were labeled by immunohistochemistry on postnatal day 60. The spatial distribution of parvalbumin interneurons was studied using Voronoi spatial tessellation and their dendritic trees were completely reconstructed. Parvalbumin interneurons of ethanol-treated animals showed a clustered spatial distribution similar to that observed in control animals. The dendritic tree of parvalbumin interneurons was significantly reduced in ethanol-treated animals, as compared with controls. Striatal parvalbumin interneurons are crucial components of the brain network serving motor control. Therefore, the shrinkage of their dendrites could contribute to the motor and cognitive symptoms observed in fetal alcohol spectrum disorder.
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DOI：
10.1111/j.1530-0277.2011.01476.x
发表时间：
2011-08-01
影响因子：
3.2
作者：
Nardelli, Alexa;Lebel, Catherine;Beaulieu, Christian
通讯作者：
Beaulieu, Christian
影响因子：
5.3
作者：
Morishima, M;Kawaguchi, Y
通讯作者：
Kawaguchi, Y
影响因子：
--
作者：
ABERCROMBIE, M
通讯作者：
ABERCROMBIE, M
影响因子：
3.8
作者：
Granato, A;Di Rocco, F;Giannetti, S
通讯作者：
Giannetti, S
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J