Do patients with familial nonmedullary thyroid cancer present with more aggressive disease? Implications for initial surgical treatment.
Do patients with familial nonmedullary thyroid cancer present with more aggressive disease? Implications for initial surgical treatment.
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DOI：
10.1016/j.surg.2018.05.075
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发表时间：
2019-01
期刊：
影响因子：
3.8
通讯作者：
Kebebew E
中科院分区：
文献类型：
--
作者：
El Lakis M;Giannakou A;Nockel PJ;Wiseman D;Gara SK;Patel D;Sater ZA;Kushchayeva YY;Klubo-Gwiezdzinska J;Nilubol N;Merino MJ;Kebebew E
关于家族性非髓样甲状腺癌是否比散发性非髓样甲状腺癌更具侵袭性的报道存在矛盾。我们的目的是确定家族性非髓样甲状腺癌的临床和病理特征是否与非髓样甲状腺癌不同。我们将家族性非髓样甲状腺癌患者与来自监测、流行病学和最终结果数据库的53,571例非髓样甲状腺癌患者进行比较。与监测、流行病学和最终结果队列相比，来自31种家族性非髓样甲状腺癌的78例患者出现年龄较轻（P = 0.04）， T1疾病（P = 0.019）、淋巴结转移（P = 0.002）和组织学上乳头状甲状腺癌的典型变异（P < 0.001）的发生率更高。家庭成员≥3人的患者出现年龄较轻（P= 0.04），男女比例较小（P= 0.04），淋巴结转移率较高（P= 0.009）。与监测、流行病学和最终结果队列相比，我们发现家族性非髓样甲状腺癌指数病例中淋巴结转移的患病率较高（P = 0.003），而超声筛查诊断的病例中淋巴结转移的患病率较低（P = 0.58）。家族性非髓样甲状腺癌患者年龄较轻，淋巴结转移率较高。家族性非髓样甲状腺癌的治疗对于临床出现的患者和有3个以上一级亲属受影响的患者应更加积极。
There are conflicting reports on whether familial nonmedullary thyroid cancer is more aggressive than sporadic nonmedullary thyroid cancer. Our aim was to determine if the clinical and pathologic characteristics of familial nonmedullary thyroid cancer are different than nonmedullary thyroid cancer. We compared patients with familial nonmedullary thyroid cancer to a cohort of 53,571 nonmedullary thyroid cancer patients from the Surveillance, Epidemiology, and End Results database. A total of 78 patients with familial nonmedullary thyroid cancer from 31 kindreds presented at a younger age (P =.04) and had a greater rate of T1 disease (P =.019), lymph node metastasis (P =.002), and the classic variant of papillary thyroid cancer on histology (P < .001) compared with the Surveillance, Epidemiology, and End Results cohort. Patients with ≥3 affected family members presented at a younger age (P = .04), had a lesser female-to-male ratio (P=.04), and had a greater rate of lymph node metastasis (P =.009). Compared with the Surveillance, Epidemiology, and End Results cohort, we found a higher prevalence of lymph node metastasis in familial nonmedullary thyroid cancer index cases (P =.003) but not in those diagnosed by screening ultrasonography (P =.58). Patients with familial nonmedullary thyroid cancer present at a younger age and have a greater rate of lymph node metastasis. The treatment for familial nonmedullary thyroid cancer should be more aggressive in patients who present clinically and in those who have ≥3 first-degree relatives affected.
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影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
6.6
作者：
Klubo-Gwiezdzinska, Joanna;Yang, Lily;Kebebew, Electron
通讯作者：
Kebebew, Electron
影响因子：
5.8
作者：
Pinto, Antonio E.;Silva, Giovani L.;Cavaco, Branca M.
通讯作者：
Cavaco, Branca M.
DOI：
10.1590/s0004-27302011000300007
发表时间：
2011-04-01
期刊：
Arquivos Brasileiros de Endocrinologia & Metabologia
影响因子：
--
作者：
Pitoia, Fabián;Cross, Graciela;Niepomniszcze, Hugo
通讯作者：
Niepomniszcze, Hugo
影响因子：
--
作者：
McDonald, Thomas J.;Driedger, Albert A.;Malchoff, Carl D.
通讯作者：
Malchoff, Carl D.