Tissue mechanics regulates form, function, and dysfunction.
Tissue mechanics regulates form, function, and dysfunction.
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DOI:
10.1016/j.ceb.2018.05.012
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发表时间:
2018-10
影响因子:
7.5
通讯作者:
Nelson CM
中科院分区:
文献类型:
--
作者:
Anlaş AA;Nelson CM
Morphogenesis describes the developmental processes that reorganize groups of cells into functional tissues and organs. The spatiotemporal patterning of individual cell behaviors is influenced by how cells perceive and respond to mechanical forces, and determines final tissue architecture. Here, we review recent work examining the physical mechanisms of tissue morphogenesis in vertebrate and invertebrate models, discuss how epithelial cells employ contractility to induce global changes that lead to tissue folding, and describe how tissue form itself is a regulator of cell behavior. We then highlight novel tools to recapitulate these processes in engineered tissues.
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