Fast quantitative three-dimensional ultrashort echo time (UTE) Cones magnetic resonance imaging of major tissues in the knee joint using extended sprial sampling.
Fast quantitative three-dimensional ultrashort echo time (UTE) Cones magnetic resonance imaging of major tissues in the knee joint using extended sprial sampling.
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DOI：
10.1002/nbm.4376
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发表时间：
2020-10
影响因子：
2.9
通讯作者：
Du J
中科院分区：
文献类型：
--
作者：
Wan L;Ma Y;Yang J;Jerban S;Searleman AC;Carl M;Le N;Chang EY;Tang G;Du J
本研究旨在探讨在3T场强下，延长螺旋采样窗口对膝关节主要组织（包括关节软骨、半月板、肌腱和韧带）的定量三维超短回波时间（UTE）Cones成像的影响。在一台3T临床磁共振成像（MRI）扫描仪上对9例人体尸体全膝关节标本进行成像。使用不同持续时间的螺旋采样轨迹估算了一系列定量三维UTE Cones成像生物标志物，包括T2*、T1、绝热T1ρ、磁化传递率（MTR）和大分子分数（MMF）。以非拉伸螺旋轨迹作为参考标准，评估了UTE MRI生物标志物误差随采样时间的变化。通过双因素方差分析（ANOVA）及双侧Dunnett检验评估，在计算得到的T2*、T1、绝热T1ρ、MTR和MMF中，将螺旋采样窗口从1116微秒增加到2232微秒时未观察到显著差异，因为所有P值均大于0.05。尽管延长采样窗口会导致短T2成分的信号丢失，但对计算得到的定量生物标志物影响有限，在所有评估的组织中误差百分比通常小于5%。在膝关节任何评估的主要组织中，定量误差小于5%的情况下，总扫描时间可减少多达54%，这表明通过使用更长的螺旋采样窗口，三维UTE Cones MRI技术可大幅加速，且不会产生额外的定量偏差。
The purpose of this study is to investigate the effect of extending the spiral sampling window on quantitative 3D UTE Cones imaging of major knee joint tissues including articular cartilage, menisci, tendons, and ligaments at 3T. Nine cadaveric human whole knee specimens were imaged on a 3T clinical MRI scanner. A series of quantitative 3D UTE Cones imaging biomarkers including T2*, T1, Adiabatic T1ρ, magnetization transfer ratio (MTR), and macromolecular fraction (MMF) were estimated using spiral sampling trajectories with various durations. Errors in UTE MRI biomarkers as a function of sampling time were evaluated using a non-stretched spiral trajectory as reference standard. No significant differences were observed by increasing the spiral sampling window from 1116 μs to 2232 μs in the calculated T2*, T1, Adiabatic T1ρ, MTR, and MMF, as all p-values were over 0.05 as assessed by ANOVA with two-sided Dunnett’s test. Although extending the sampling window results in signal loss for short T2 components, there was limited effect on the calculated quantitative biomarkers, with error percentages typically smaller than 5% in all evaluated tissues. The total scan time can be reduced by up to 54% with quantification errors less than 5% in any evaluated major tissue in the knee joint, suggesting that the 3D UTE Cones MRI techniques can be greatly accelerated by using a longer spiral sampling window without causing additional quantitative bias.
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影响因子：
2.4
作者：
Jerban S;Nazaran A;Cheng X;Carl M;Szeverenyi N;Du J;Chang EY
通讯作者：
Chang EY
影响因子：
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作者：
Li C;Magland JF;Seifert AC;Wehrli FW
通讯作者：
Wehrli FW
影响因子：
3.3
作者：
Gurney, PT;Hargreaves, BA;Nishimura, DG
通讯作者：
Nishimura, DG
影响因子：
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作者：
Dournes, Gael;Grodzki, David;Laurent, Francois
通讯作者：
Laurent, Francois
影响因子：
27.4
作者：
Tan, A. L.;Toumi, H.;McGonagle, D.
通讯作者：
McGonagle, D.