Ultrashort echo time T2(∗) values decrease in tendons with application of static tensile loads.
Ultrashort echo time T2(∗) values decrease in tendons with application of static tensile loads.
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DOI：
10.1016/j.jbiomech.2017.07.018
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发表时间：
2017-08-16
影响因子：
2.4
通讯作者：
Chang EY
中科院分区：
文献类型：
--
作者：
Jerban S;Nazaran A;Cheng X;Carl M;Szeverenyi N;Du J;Chang EY
在肌腱疾病的早期阶段，力学性质可能在形态解剖改变之前发生改变。超短回波时间(UTE)磁共振成像(MRI)可用于直接检测T2值非常短的组织的信号，包括独特的粘弹性组织，如肌腱。本研究的目的是利用UTE序列测量肌腱样品在静态拉伸载荷下的T2*、T1和磁化传递比(MTR)的变化。在临床3T磁共振扫描仪上使用UTE序列对6条人体腓骨肌腱在静态载荷前和静态载荷下进行成像。肌腱分为两组：A组为一步加载(15 N)，B组为两步加载(15 N和30 N)。研究了两个选定的感兴趣区的T2*、T1和MTR变化，包括全断面和核心断面。第一步加载时，A组和B组在全断面和核心断面感兴趣区的T2*值分别下降了13±7%(P=0.028)和16±5%(P=0.017)。在第二次加载阶段(B组)，全断面和核心断面的T2*值分别下降了9±2%(P=0.059)和7±5%(P=0.121)，但无显著差异。平均T1在两个加载步骤中都没有显示出任何一致的变化(P&gT；0.05)。平均MTR略有增加，但在两个加载步骤中并不显著(P&gT；0.05)。施加静态拉伸载荷后，肌腱的T2*值仅有显著差异。因此，建议在加载过程中监测T2*，以定量研究肌腱的生物力学。
In early stages of tendon disease, mechanical properties may become altered prior to changes in morphological anatomy. Ultrashort echo time (UTE) magnetic resonance imaging (MRI) can be used to directly detect signal from tissues with very short T2 values, including unique viscoelastic tissues such as tendons. The purpose of this study was to use UTE sequences to measure T2*, T1 and magnetization transfer ratio (MTR) variations of tendon samples under static tensile loads. Six human peroneal tendons were imaged before and under static loading using UTE sequences on a clinical 3T MRI scanner. Tendons were divided into two static tensile loading groups: group A that underwent one-step loading (15 N) and group B that underwent two-step loading (15 and 30 N). The T2*, T1 and MTR variations were investigated in two selected ROIs, including whole and core sections. Mean T2* values for the first step of loading (groups A and B) in both whole section and core section regions of interest (ROIs) were significantly decreased by 13 ± 7% (P=0.028) and 16 ± 5% (P=0.017), respectively. For the second loading step (group B), there was a consistent, but non-significant reduction in T2* value by 9 ±2% (P=0.059) and 7 ± 5% (P=0.121) for whole and core sections, respectively. Mean T1 did not show any consistent changes for either loading steps (P>0.05). Mean MTR increased slightly, but not significantly for both loading steps (P>0.05). Significant differences were found only in T2* values of tendons by static tensile load application. Therefore, T2* monitoring during loading is suggested for quantitative investigation of the tendons biomechanics.
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影响因子：
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作者：
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影响因子：
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