Retinal waves coordinate patterned activity throughout the developing visual system.
Retinal waves coordinate patterned activity throughout the developing visual system.
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DOI：
10.1038/nature11529
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发表时间：
2012-10-11
期刊：
影响因子：
64.8
通讯作者：
Crair MC
中科院分区：
文献类型：
--
作者：
Ackman JB;Burbridge TJ;Crair MC
脊椎动物神经系统的形态和功能发育最初是由遗传因素决定的，后来又由神经元活动决定。然而，神经系统的基本特征在感觉体验成为可能之前就已经出现了。因此，在体验开始之前发生的依赖活动的发育必须由自发活动驱动，但体内活动的起源和性质在很大程度上仍未得到检验。在这里，我们使用光学方法在活体新生小鼠身上演示了自发视网膜活动波的存在，并在睁开眼睛之前传播到整个视觉系统。这种模式活动围绕视野，依赖于胆碱能神经传递，优先在双眼视网膜启动，并显示出两个半球之间的时空相关性。视网膜波是中脑和初级视觉皮质活动的主要来源，但只调节次级视觉区域正在进行的活动。因此，自发的视网膜活动通过整个视觉系统传递，并携带有模式的信息，能够在视觉开始之前引导复杂的大脑半球内和大脑间回路的活动依赖的发展。
The morphologic and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal activity. However, fundamental features of the nervous system emerge before sensory experience is possible. Thus, activity-dependent development occurring before the onset of experience must be driven by spontaneous activity, but the origin and nature of activity in vivo remains largely untested. Here we use optical methods to demonstrate in live neonatal mice that waves of spontaneous retinal activity are present and propagate throughout the entire visual system before eye opening. This patterned activity encompassed the visual field, relied on cholinergic neurotransmission, preferentially initiated in the binocular retina, and exhibited spatiotemporal correlations between the two hemispheres. Retinal waves were the primary source of activity in the midbrain and primary visual cortex, but only modulated ongoing activity in secondary visual areas. Thus, spontaneous retinal activity is transmitted through the entire visual system and carries patterned information capable of guiding the activity-dependent development of complex intra- and inter- hemispheric circuits before the onset of vision.
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影响因子：
14.8
作者：
Garaschuk, Olga;Milos, Ruxandra-Iulia;Konnerth, Arthur
通讯作者：
Konnerth, Arthur
DOI：
10.1073/pnas.87.7.2861
发表时间：
1990-04-01
影响因子：
11.1
作者：
MAFFEI, L;GALLIRESTA, L
通讯作者：
GALLIRESTA, L
影响因子：
16.2
作者：
Elstrott, Justin;Anishchenko, Anastasia;Feller, Marla B.
通讯作者：
Feller, Marla B.
影响因子：
5.3
作者：
Colonnese, Matthew T.;Khazipov, Rustem
通讯作者：
Khazipov, Rustem
DOI：
10.1523/jneurosci.5309-12.2012
发表时间：
2012-01-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ford KJ;Félix AL;Feller MB
通讯作者：
Feller MB