Paracrine Effects of Fetal Stem Cells
Paracrine Effects of Fetal Stem Cells
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胎儿干细胞的旁分泌作用
DOI：
10.1007/978-1-4939-3483-6_3
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发表时间：
2016
影响因子：
2.6
通讯作者：
J. Ratajczak
中科院分区：
文献类型：
--
作者：
M. Ratajczak;Gabriela Schneider;J. Ratajczak
胚胎干细胞（ESC）是能够分化成属于所有三个胚层的细胞的多能干细胞。不幸的是，它们在临床应用中的主要问题是它们在宿主组织中生长畸胎瘤。然而，ESC还分泌几种可溶性因子（肽、生物活性脂质、细胞外核苷酸）以及从细胞表面脱落或从内体隔室分泌的小的球形膜片段;称为细胞外微泡（ExMV）。这些旁分泌介质在细胞间通讯和组织/器官发育中起重要作用，可用于再生医学。因此，直到开发出将在临床中利用ESC的体内应用的适当策略，从体外培养的ESC收获的富含可溶性因子和ExMV的条件培养基可以在再生医学中用作治疗受损器官的治疗剂。称为argosomes的ExMV也在胚胎发生期间由一些胎儿细胞分泌，并参与组织模式和器官发育。在本章中，我们将讨论在体外产生的胚胎干细胞衍生的旁分泌因子作为一种选择，利用这些细胞在再生医学的治疗潜力的潜在应用。
Embryonic stem cells (ESCs) are pluripotent stem cells able to differentiate into cells belonging to all three germ layers. Unfortunately, the major problem with their application in the clinic is that they grow teratomas in the host tissues. Nevertheless, ESCs secrete also several soluble factors (peptides, bioactive lipids, extracellular nucleotides) as well small, spherical membrane fragments that are shed from the cell surface or secreted from the endosomal compartment; called extracellular microvesicles (ExMVs). These paracrine mediators play an important role in cell–cell communication and tissue/organ development and could be employed in regenerative medicine. Thus, until appropriate strategies that will harness in vivo application of ESCs in the clinic will be developed, conditioned media harvested from cultured in vitro ESCs, enriched in soluble factors and ExMVs, could be employed in regenerative medicine as therapeutics to treat damaged organs. ExMVs known as argosomes are also secreted during embryogenesis by some fetal cells and are involved in tissue patterning and organ development. In this chapter we will discuss potential applications of in vitro generated ESCs-derived paracrine factors as an option to harness therapeutic potential of these cells in regenerative medicine.
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影响因子：
4
作者：
J. Ratajczak;M. Kucia;Kasia Mierzejewska;W. Marlicz;Z. Pietrzkowski;W. Wojakowski;N. Greco;M. Tendera;M. Ratajczak
通讯作者：
J. Ratajczak;M. Kucia;Kasia Mierzejewska;W. Marlicz;Z. Pietrzkowski;W. Wojakowski;N. Greco;M. Tendera;M. Ratajczak
影响因子：
20.3
作者：
Majka, M;Janowska-Wieczorek, A;Ratajczak, MZ
通讯作者：
Ratajczak, MZ
DOI：
10.1253/circj.cj-09-0923
发表时间：
2010-03
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
Tang XL;Rokosh DG;Guo Y;Bolli R
通讯作者：
Bolli R
影响因子：
12.8
作者：
M. Ratajczak;E. Zuba-Surma;M. Wysoczynski;Wu Wan;J. Ratajczak;W. Wojakowski;M. Kucia
通讯作者：
M. Ratajczak;E. Zuba-Surma;M. Wysoczynski;Wu Wan;J. Ratajczak;W. Wojakowski;M. Kucia
影响因子：
2.6
作者：
Quesenberry, Peter J.;Dooner, Mark S.;Aliotta, Jason M.
通讯作者：
Aliotta, Jason M.