Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.
Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.
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DOI：
10.1146/annurev-ecolsys-031120-101013
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gould F
中科院分区：
文献类型：
--
作者：
Dhole S;Lloyd AL;Gould F
合成基因驱动的传播经常在由基因流连接的泛群的背景下讨论，并用简单的确定性模型来描述。在这样的假设下，释放一个携带侵入性基因驱动的个体，比如标准的归巢驱动，就可以改变整个物种。虽然这仍然是一种理论上的可能性，但基因驱动在自然种群中的传播更为复杂，值得更现实的评估。在种群中释放的任何基因驱动的命运都将与种群的生态密不可分。考虑到自然种群生态评估中经常涉及的不确定性，了解基因驱动传播对重要生态因子的敏感性至关重要。本文回顾了不同形式的密度依赖、空间异质性和交配行为如何影响自我维持基因驱动的传播。我们强调了基因驱动动力学的具体方面和需要进一步研究的目标人群。
The spread of synthetic gene drives is often discussed in the context of panmictic populations connected by gene flow and described with simple deterministic models. Under such assumptions, an entire species could be altered by releasing a single individual carrying an invasive gene drive, such as a standard homing drive. While this remains a theoretical possibility, gene drive spread in natural populations is more complex and merits a more realistic assessment. The fate of any gene drive released in a population would be inextricably linked to the population’s ecology. Given the uncertainty often involved in ecological assessment of natural populations, understanding the sensitivity of gene drive spread to important ecological factors is critical. Here we review how different forms of density dependence, spatial heterogeneity, and mating behaviors can impact the spread of self-sustaining gene drives. We highlight specific aspects of gene drive dynamics and the target populations that need further research.
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影响因子：
3.3
作者：
Beaghton A;Hammond A;Nolan T;Crisanti A;Godfray HC;Burt A
通讯作者：
Burt A
DOI：
10.1098/rsif.2013.1071
发表时间：
2014-04-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Alphey N;Bonsall MB
通讯作者：
Bonsall MB
DOI：
10.1073/pnas.1713139115
发表时间：
2018-05-01
影响因子：
11.1
作者：
Buchman, Anna;Marshall, John M.;Akbari, Omar S.
通讯作者：
Akbari, Omar S.
影响因子：
4.7
作者：
Akbari, Omar S.;Chen, Chun-Hong;Hay, Bruce A.
通讯作者：
Hay, Bruce A.
影响因子：
1.4
作者：
Beaghton, Andrea;Beaghton, Pantelis John;Burt, Austin
通讯作者：
Burt, Austin