Interplay of population genetics and dynamics in the genetic control of mosquitoes.
Interplay of population genetics and dynamics in the genetic control of mosquitoes.
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DOI：
10.1098/rsif.2013.1071
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发表时间：
2014-04-06
期刊：
影响因子：
--
通讯作者：
Bonsall MB
中科院分区：
文献类型：
--
作者：
Alphey N;Bonsall MB
一些提出的基于遗传学的病媒控制方法旨在以与昆虫不育技术类似的方式抑制或消灭蚊子种群。在按蚊中正在开发的一种方法使用归巢核酸内切酶基因（HEGs）-自私的遗传因子（以大于孟德尔的速度遗传），即使它们降低了适应性，也可以在种群中迅速传播。HEGs有可能在没有大规模持续释放的情况下通过种群驱动引入的性状。已使用离散时间数学模型建立了基于HG的系统的群体遗传学。然而，几个生态上重要的方面仍然没有探索。我们制定了一个新的连续时间（重叠世代）相结合的人口动态和遗传模型，并将其应用到HEG的目标和敲除的基因，是重要的生存。我们探讨了密度依赖性的影响，从补偿不足，过度补偿幼虫竞争，发生在HEG健身效果之前或之后，并考虑基因型（野生型，杂合子和HEG纯合子）之间的竞争效应的差异。我们表明，人口的结果消除，抑制或损失的HEG，关键取决于这些生态方面和遗传之间的相互作用，并解释如何HEG健身属性，归巢率（驱动器）和昆虫的生活史参数影响这些结果。
Some proposed genetics-based vector control methods aim to suppress or eliminate a mosquito population in a similar manner to the sterile insect technique. One approach under development in Anopheles mosquitoes uses homing endonuclease genes (HEGs)—selfish genetic elements (inherited at greater than Mendelian rate) that can spread rapidly through a population even if they reduce fitness. HEGs have potential to drive introduced traits through a population without large-scale sustained releases. The population genetics of HEG-based systems has been established using discrete-time mathematical models. However, several ecologically important aspects remain unexplored. We formulate a new continuous-time (overlapping generations) combined population dynamic and genetic model and apply it to a HEG that targets and knocks out a gene that is important for survival. We explore the effects of density dependence ranging from undercompensating to overcompensating larval competition, occurring before or after HEG fitness effects, and consider differences in competitive effect between genotypes (wild-type, heterozygotes and HEG homozygotes). We show that population outcomes—elimination, suppression or loss of the HEG—depend crucially on the interaction between these ecological aspects and genetics, and explain how the HEG fitness properties, the homing rate (drive) and the insect's life-history parameters influence those outcomes.
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影响因子：
3.7
作者：
Beck-Johnson LM;Nelson WA;Paaijmans KP;Read AF;Thomas MB;Bjørnstad ON
通讯作者：
Bjørnstad ON
影响因子：
3
作者：
Depinay, JMO;Mbogo, CM;McKenzie, FE
通讯作者：
McKenzie, FE
影响因子：
3.4
作者：
Klein, T. A.;Windbichler, N.;Benedict, M. Q.
通讯作者：
Benedict, M. Q.
影响因子：
5.7
作者：
CLEMENTS, AN;PATERSON, GD
通讯作者：
PATERSON, GD
影响因子：
2.1
作者：
Gilles, J. R. L.;Lees, R. S.;Benedict, M. Q.
通讯作者：
Benedict, M. Q.