Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users.
Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users.
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在大麻使用者中，与性别相关的主观差异，但没有神经，提示引起的渴望反应。
DOI：
10.1016/j.drugalcdep.2020.107931
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发表时间：
2020-04-01
影响因子：
4.2
通讯作者：
Filbey FM
中科院分区：
文献类型：
--
作者：
Prashad S;Hammonds RP;Wiese AL;Milligan AL;Filbey FM
研究表明，女性吸食大麻的人比男性吸食大麻的人在大麻使用障碍(CUD)的里程碑阶段进展得更快，这可能是因为女性的主观渴望反应比男性更大。虽然研究已经报道了与性别有关的主观渴望的差异，但神经反应的差异以及神经和行为反应的相对贡献仍不清楚。我们考察了112名重度大麻使用者(54名女性)对大麻线索和大麻使用措施的神经和行为反应的性别差异。我们使用主成分分析来确定神经和行为反应以及大麻使用措施的相对贡献。我们发现，在数据集中解释最大方差的主成分(PC)1与对大麻线索的神经反应相关，而男性和女性使用者之间没有差异(p=0.21)。第二大变量PC2与主观渴望相关，女性用户比男性用户表现出更大的主观渴望(p=0.003)。我们还发现CUD症状与PC1和PC2相关，证实了渴望与CUD严重程度之间的关系。这些结果表明，神经活动主要是对大麻线索的反应，一种复杂的关系表现为收敛的神经反应和发散的主观渴望反应，这在性别之间是不同的。考虑到这些差异，将通过个性化的方法提高治疗效果。
Studies indicate that female cannabis users progress through the milestones of cannabis use disorder (CUD) more quickly than male users, likely due to greater subjective craving response in women relative to men. While studies have reported sex-related differences in subjective craving, differences in neural response and the relative contributions of neural and behavioral response remain unclear. We examined sex-related differences in neural and behavioral response to cannabis cues and cannabis use measures in 112 heavy cannabis users (54 females). We used principal component analysis to determine the relative contributions of neural and behavioral response and cannabis use measures. We found that principal component (PC) 1, which accounts for the most variance in the dataset, was correlated with neural response to cannabis cues with no differences between male and female users (p = 0.21). PC2, which accounts for the second-most variance, was correlated with subjective craving such that female users exhibited greater subjective craving relative to male users (p = 0.003). We also found that CUD symptoms correlated with both PC1 and PC2, corroborating the relationship between craving and CUD severity. These results indicate that neural activity primarily underlies response to cannabis cues and that a complex relationship characterizes a convergent neural response and a divergent subjective craving response that differs between the sexes. Accounting for these differences will increase efficacy of treatments through personalized approaches.
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影响因子：
3.2
作者：
Abdi, Herve;Williams, Lynne J.
通讯作者：
Williams, Lynne J.
DOI：
10.3109/00952990.2015.1049701
发表时间：
2015
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
DeWitt SJ;Ketcherside A;McQueeny TM;Dunlop JP;Filbey FM
通讯作者：
Filbey FM
影响因子：
4.4
作者：
Dickmann, Patricia J.;Mooney, Marc E.;Hatsukami, Dorothy K.
通讯作者：
Hatsukami, Dorothy K.
影响因子：
4.2
作者：
DeVito, Elise E.;Babuscio, Theresa A.;Carroll, Kathleen M.
通讯作者：
Carroll, Kathleen M.
影响因子：
3.4
作者：
Cousijn, Janna;Goudriaan, Anna E.;Wiers, Reinout W.
通讯作者：
Wiers, Reinout W.