Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation.
Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation.
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DOI：
10.1038/s42003-021-02561-9
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发表时间：
2021-09-09
影响因子：
5.9
通讯作者：
Jansen G
中科院分区：
文献类型：
--
作者：
Dekkers MPJ;Salfelder F;Sanders T;Umuerri O;Cohen N;Jansen G
对知觉的传统理解赋予感觉器官捕捉环境的作用。更好的传感器导致更准确的刺激编码，允许下游的认知处理。本研究表明，感觉神经元的可塑性介导了秀丽隐杆线虫在naïve动物对NaCl的吸引和预处理动物对NaCl的回避之间的行为转换，这被称为味觉可塑性。ASE和ASH NaCl感知神经元的Ca2+成像揭示了多种细胞自主和分布式电路适应机制。计算模型定量地解释了观察到的行为，并揭示了感觉神经元在运动行为、决策和导航策略的控制和调节中的作用。感觉适应动态地改变环境的编码。因此，我们建议这些秀丽隐杆线虫的传感器动态编码一个与上下文相关的刺激值，而不是直接编码刺激。我们的研究结果证明了适应性感官计算如何直接控制动物的行为状态。Martijn Dekkers和Felix Salfelder等人结合实验方法和数学模型，确定了秀丽隐杆线虫中两个主要的NaCl感觉神经元（称为ASEL和ASER）和伤害感觉神经元（称为ASH）在NaCl吸引和回避之间的上下文依赖转换中的作用。他们的研究结果表明，这些感觉神经元对NaCl的敏感性调节使动物能够动态调节其行为反应，并表明感觉调节在觅食过程中平衡探索和利用方面的作用。
A conventional understanding of perception assigns sensory organs the role of capturing the environment. Better sensors result in more accurate encoding of stimuli, allowing for cognitive processing downstream. Here we show that plasticity in sensory neurons mediates a behavioral switch in C. elegans between attraction to NaCl in naïve animals and avoidance of NaCl in preconditioned animals, called gustatory plasticity. Ca2+ imaging in ASE and ASH NaCl sensing neurons reveals multiple cell-autonomous and distributed circuit adaptation mechanisms. A computational model quantitatively accounts for observed behaviors and reveals roles for sensory neurons in the control and modulation of motor behaviors, decision making and navigational strategy. Sensory adaptation dynamically alters the encoding of the environment. Rather than encoding the stimulus directly, therefore, we propose that these C. elegans sensors dynamically encode a context-dependent value of the stimulus. Our results demonstrate how adaptive sensory computation can directly control an animal’s behavioral state. Martijn Dekkers and Felix Salfelder et al. combine experimental approaches and mathematical modeling to determine the contribution of the two main NaCl sensory neurons (termed ASEL and ASER) and the nociceptive neurons (termed ASH) in C. elegans to the context-dependent switching between NaCl attraction and avoidance. Their results show that regulated sensitivity of these sensory neurons to NaCl allows the animal to dynamically modulate its behavioral response and suggest a role for sensory modulation in balancing exploration and exploitation during foraging.
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