Copper selenide nanocrystals for photothermal therapy.
Copper selenide nanocrystals for photothermal therapy.
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DOI:
10.1021/nl201400z
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发表时间:
2011-06-08
期刊:
影响因子:
10.8
通讯作者:
Korgel BA
中科院分区:
文献类型:
--
作者:
Hessel CM;Pattani VP;Rasch M;Panthani MG;Koo B;Tunnell JW;Korgel BA
Ligand-stabilized copper selenide (Cu2−xSe) nanocrystals, approximately 16 nm in diameter, were synthesized by a colloidal hot injection method and coated with amphiphilic polymer. The nanocrystals readily disperse in water and exhibit strong near infrared (NIR) optical absorption with a high molar extinction coefficient of 7.7 × 107 cm−1 M−1 at 980 nm. When excited with 800 nm light, the Cu2−xSe nanocrystals produce significant photothermal heating with a photothermal transduction efficiency of 22%, comparable to nanorods and nanoshells of gold (Au). In vitro photothermal heating of Cu2−xSe nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 minutes of laser irradiation at 33 W/cm2, demonstrating the viabilitiy of Cu2−xSe nanocrystals for photothermal therapy applications.
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