Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness.
Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness.
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DOI：
10.1007/s00395-011-0201-0
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发表时间：
2011-11
影响因子：
9.5
通讯作者：
Lucchesi PA
中科院分区：
文献类型：
--
作者：
Katz PS;Trask AJ;Souza-Smith FM;Hutchinson KR;Galantowicz ML;Lord KC;Stewart JA Jr;Cismowski MJ;Varner KJ;Lucchesi PA
2型糖尿病（DM）对冠状动脉重构的影响目前尚不清楚。本研究的目的是确定2型糖尿病（db/db）小鼠冠状动脉结构重塑的机制。被动结构特性的间隔冠状动脉分离12和16周龄糖尿病db/db和对照组小鼠进行了评估，压力肌电图。来自12周龄db/db小鼠的冠状小动脉在结构上与年龄匹配的对照相似。到16周龄时，db/db小动脉的冠状动脉壁厚度增加（p < 0.01），而管腔直径减小（对照：118±5μm; db/db：102±4μm，p < 0.05），壁腔比增加58%（对照：5.9±0.6; db/db：9.5±0.4，p < 0.001）。糖尿病小鼠的向内肥厚性重构伴随着弹性模量降低56%（p < 0.05，表明血管冠状动脉壁硬度降低）和冠状动脉血流储备降低约30%。有趣的是，db/db小鼠的主动脉脉搏波速度和股动脉增量模量增加（p < 0.05），表明大血管僵硬。分子组织分析显示，与对照组相比，糖尿病冠状动脉中弹性蛋白与胶原蛋白的比例增加，而糖尿病冠状动脉中弹性蛋白与胶原蛋白的比例降低。这些数据显示，从2型糖尿病小鼠分离的冠状小动脉经历与刚度降低和弹性蛋白与胶原蛋白比率增加相关的向内肥大性重构，这导致冠状动脉血流储备降低。这项研究表明，冠状动脉微血管经历了不同的模式，从大血管在2型糖尿病的重塑。
Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling in type 2 diabetic (db/db) mice. Passive structural properties of septal coronary arterioles isolated from 12- and 16-wk-old diabetic db/db and control mice were assessed by pressure myography. Coronary arterioles from 12-wk-old db/db mice were structurally similar to age-matched controls. By 16-wks of age, coronary wall thickness was increased in db/db arterioles (p < 0.01), while luminal diameter was reduced (Control: 118±5μm; db/db: 102±4μm, p < 0.05), augmenting the wall-to-lumen ratio by 58% (Control: 5.9±0.6; db/db: 9.5±0.4, p < 0.001). Inward hypertrophic remodeling was accompanied by a 56% decrease in elastic modulus (p < 0.05, indicating decreased vessel coronary wall stiffness) and a ~30% reduction in coronary flow reserve in diabetic mice. Interestingly, aortic pulse wave velocity and femoral artery incremental modulus were increased (p < 0.05) in db/db mice, indicating macrovascular stiffness. Molecular tissue analysis revealed increased elastin-to-collagen ratio in diabetic coronaries when compared to control and a decrease in the same ratio in the diabetic aortas. These data show that coronary arterioles isolated from type 2 diabetic mice undergo inward hypertrophic remodeling associated with decreased stiffness and increased elastin-to-collagen ratio which results in a decreased coronary flow reserve. This study suggests that coronary microvessels undergo a different pattern of remodeling from macrovessels in type 2 DM.
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DOI：
10.1161/01.atv.0000252068.89775.ee
发表时间：
2007-01-01
影响因子：
8.7
作者：
Bodary, Peter F.;Shen, Yuechun;Eitzman, Daniel T.
通讯作者：
Eitzman, Daniel T.
影响因子：
3.3
作者：
Jin, KL;Mao, XO;Greenberg, DA
通讯作者：
Greenberg, DA
影响因子：
1.7
作者：
Beaucage, P;Yamaguchi, N;Moreau, P
通讯作者：
Moreau, P
影响因子：
2
作者：
Deedwania, Prakash;Srikanth, Sundararajan
通讯作者：
Srikanth, Sundararajan
影响因子：
2.9
作者：
Hartley, Craig J.;Reddy, Anilkumar K.;Taffet, George E.
通讯作者：
Taffet, George E.