Evaluation of Dosimetric Effect of Bone Scatter on Nanoparticle-Enhanced Orthovoltage Radiotherapy: A Monte Carlo Phantom Study.
Evaluation of Dosimetric Effect of Bone Scatter on Nanoparticle-Enhanced Orthovoltage Radiotherapy: A Monte Carlo Phantom Study.
复制标题
DOI：
10.3390/nano12172991
复制
发表时间：
2022-08-29
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
在纳米粒子（NP）增强的正电压放疗中，骨散射影响前额、胸壁和膝盖等皮肤病变区域的剂量增强。由于每个治疗部位在皮肤病变下方都有骨，如额骨、肋骨或髌骨，并且在剂量传递计算中不考虑该骨，因此在放射治疗中添加NPs后的剂量增强评估中出现了不确定性。为了研究忽略骨散射效应的影响，进行了基于异质幻影的蒙特卡罗模拟，以确定和比较皮肤病变下存在骨和不存在骨时的剂量增强比（DER）。对于添加了NPs的皮肤病变，使用蒙特卡罗模拟计算了不同元素NPs（金、铂、银、碘和氧化铁）在不同NP浓度（3-40 mg/mL）下，在两种不同光子束能量（105和220 kVp）下的DER值。研究发现，当NP原子序数较高、NP浓度较高、光子束流能量较低时，皮肤病变处的DER值随骨的存在而增加。在相同的NP元素、NP浓度和光束能量下，比较带骨和不带骨的DER值，差异在0.04 ~ 3.55%之间，且随着NP浓度的增加，差异更大。考虑到DER计算中的不确定性，当NP浓度大于18 mg/mL时，骨散射对剂量增强（>.2 %）的影响显著。这导致低估了皮肤病变处的剂量增强，而在正电压放疗期间忽略了肿瘤下的骨骼。
In nanoparticle (NP)-enhanced orthovoltage radiotherapy, bone scatter affected dose enhancement at the skin lesion in areas such as the forehead, chest wall, and knee. Since each of these treatment sites have a bone, such as the frontal bone, rib, or patella, underneath the skin lesion and this bone is not considered in dose delivery calculations, uncertainty arises in the evaluation of dose enhancement with the addition of NPs in radiotherapy. To investigate the impact of neglecting the effect of bone scatter, Monte Carlo simulations based on heterogeneous phantoms were carried out to determine and compare the dose enhancement ratio (DER), when a bone was and was not present underneath the skin lesion. For skin lesions with added NPs, Monte Carlo simulations were used to calculate the DER values using different elemental NPs (gold, platinum, silver, iodine, as well as iron oxide), in varying NP concentrations (3–40 mg/mL), at two different photon beam energies (105 and 220 kVp). It was found that DER values at the skin lesion increased with the presence of bone when there was a higher atomic number of NPs, a higher NP concentration, and a lower photon beam energy. When comparing DER values with and without bone, using the same NP elements, NP concentration, and beam energy, differences were found in the range 0.04–3.55%, and a higher difference was found when the NP concentration increased. By considering the uncertainty in the DER calculation, the effect of bone scatter became significant to the dose enhancement (>2%) when the NP concentration was higher than 18 mg/mL. This resulted in an underestimation of dose enhancement at the skin lesion, when the bone underneath the tumour was neglected during orthovoltage radiotherapy.
登录
查看更多内容
影响因子：
2.7
作者：
Huynh, Ngoc Han;Chow, James C. L.
通讯作者：
Chow, James C. L.
影响因子：
8
作者：
Oh N;Park JH
通讯作者：
Park JH
影响因子：
5.5
作者：
Cooper DR;Bekah D;Nadeau JL
通讯作者：
Nadeau JL
DOI：
10.3233/jcm-2011-0358
发表时间：
2011-01-01
影响因子：
0.5
作者：
Chow, James C. L.
通讯作者：
Chow, James C. L.
影响因子：
3.5
作者：
Cho, SH
通讯作者：
Cho, SH