Update on indoor allergens and their impact on pediatric asthma.
Update on indoor allergens and their impact on pediatric asthma.
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室内过敏原及其对儿童哮喘影响的最新研究进展。
DOI：
10.1016/j.anai.2022.02.009
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发表时间：
2022-06
影响因子：
5.9
通讯作者：
Phipatanakul, Wanda
中科院分区：
文献类型：
--
作者：
Maciag, Michelle C.;Phipatanakul, Wanda
近几十年来，许多室内过敏原已被发现，包括尘螨、猫、狗、老鼠、蟑螂和室内霉菌，这些过敏原对健康有重要影响，特别是对过敏性哮喘患者。本综述旨在更新我们对室内环境中这些暴露程度的认识，审查降低其在环境中水平的策略，并强调最近针对这些暴露及其对儿科哮喘发病率影响的创新试验。参考了最近关于室内过敏原暴露的实践参数更新、开创性研究和最近的同行评审期刊文章。本综述引用了最近对特征明确的儿科哮喘患者进行的队列研究，以及评估环境过敏原暴露、限制这些暴露的干预措施及其结果的创新随机对照试验。室内空气过敏原暴露与健康结果之间的联系已经明确。然而，只有一些减少过敏原的干预措施在改善健康结果方面取得了成功。过敏暴露和健康结果涉及许多复杂的因素。患者遗传因素、室内过敏触发因素、空气中的刺激物/污染物和微生物暴露之间的相互作用使室内过敏原暴露及其对哮喘发病率影响的研究变得复杂。
In recent decades, many indoor allergens have been identified, including dust mite, cat, dog, mouse, cockroach and indoor molds, which have important health effects particularly in sensitized asthmatics. This review aims to update our understanding regarding the extent of these exposures in the indoor environment, review strategies for reducing their levels in the environment, and highlight innovative recent trials targeting these exposures and their impact on pediatric asthma morbidity. Recent practice parameter updates on indoor allergen exposures, seminal studies, and recent peer-reviewed journal articles are referenced. This review cites recent cohort studies of well-characterized pediatric asthmatic patients as well as innovative randomized controlled trials evaluating exposure to environmental allergens, interventions to limit these exposures, and their outcomes. Links between indoor aeroallergen exposures and health outcomes have been well established. However, only some allergen reduction interventions have been successful in improving health outcomes. There are many complicating factors involved in allergic exposures and health outcomes. The interplay between patient genetic factors, indoor allergic triggers, airborne irritants/pollutants and microbial exposures complicate the study of indoor allergen exposures and their impact on asthma morbidity.
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影响因子：
8
作者：
Karvonen, Anne M.;Hyvarinen, Anne;Pekkanen, Juha
通讯作者：
Pekkanen, Juha
影响因子：
14.2
作者：
Grant, Torie;Phipatanakul, Wanda;Matsui, Elizabeth C.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Woodcock, A