Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.
Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.
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DOI：
10.1136/lupus-2018-000278
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发表时间：
2018
影响因子：
3.9
通讯作者：
Busch MP
中科院分区：
文献类型：
--
作者：
Jackman RP;Cruz GI;Nititham J;Triulzi DJ;Barcellos LF;Criswell LA;Norris PJ;Busch MP
风湿性关节炎（RA）和系统性红斑狼疮（SLE）不成比例地影响妇女在生育期间和之后。抗人类白细胞抗原（HLA）同种抗体反应是常见的健康产妇，因为这些疾病都与HLA和免疫失调，我们试图评估抗HLA抗体在RA和SLE。对224例经产SLE患者、202例经产RA患者和239例健康经产对照者进行了抗HLA抗体检测，并与未经产女性和男性对照者进行了比较。鉴定抗体特异性，并与受试者HLA类型进行比较，以确定自身反应性与同种异体反应性。评估抗HLA抗体与临床结局的相关性。抗HLA抗体的水平和频率显着较高的经产女性与SLE（52%）或RA（46%）与对照组（26%）相比，和抗HLA抗体中也发现未经产的女性和男性与SLE和RA。在SLE和RA抗体阳性受试者中观察到自身反应性抗HLA抗体，但在健康对照者中未观察到，SLE受试者中发现自身反应性抗HLA抗体的频率最高。未育SLE患者血清中抗HLA抗体水平与肾炎有关（p<0.01）。抗I类HLA抗体的存在与RA和SLE初产病例中诊断时的年轻年龄相关。在RA和SLE受试者中发现高水平的自身反应性和同种异体反应性抗HLA抗体。即使在没有同种异体暴露的情况下，这些也会发生，特别是在SLE受试者中，并且可能与疾病的严重程度有关。
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) disproportionately affect women during and following childbearing years. Antihuman leucocyte antigen (HLA) alloantibody responses are common in healthy parous women, and as these diseases are both linked with HLA and immune dysregulation, we sought to evaluate anti-HLA antibodies in RA and SLE. Anti-HLA antibodies were measured among parous SLE cases (n=224), parous RA cases (n=202) and healthy parous controls (n=239) and compared with each other as well as with nulliparous female and male controls. Antibody specificities were identified and compared against subject HLA types to determine autoreactivity versus alloreactivity. The association of anti-HLA antibodies with clinical outcomes was evaluated. Levels and frequencies of anti-HLA antibodies were significantly higher among parous females with SLE (52%) or RA (46%) compared with controls (26%), and anti-HLA antibodies were also found among nulliparous females and males with SLE and RA. Autoreactive anti-HLA antibodies were observed among SLE and RA antibody-positive subjects, but not healthy controls, with the highest frequency of autoreactive anti-HLA antibodies found in the SLE subjects. Higher levels of anti-HLA antibodies were associated with nephritis among the nulliparous SLE cases (p<0.01). The presence of anti-class I HLA antibodies was associated with younger age at diagnosis among both the RA and SLE nulliparous cases. Both autoreactive and alloreactive anti-HLA antibodies were found at high levels in RA and SLE subjects. These occurred even in the absence of alloexposure, particularly among SLE subjects and may be linked with disease severity.
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影响因子：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
5
作者：
通讯作者：
--
影响因子：
158.5
作者：
NELSON, JL;HUGHES, KA;HANSEN, JA
通讯作者：
HANSEN, JA
影响因子：
20.3
作者：
PAYNE, R
通讯作者：
PAYNE, R
影响因子：
37.8
作者：
Itescu, S;Tung, TC;Michler, RE
通讯作者：
Michler, RE