The cell biology of regeneration.

The cell biology of regeneration.
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DOI:
10.1083/jcb.201105099
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发表时间:
2012-03-05
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Newmark PA
Newmark PA
中科院分区:
其他
文献类型:
--
作者:
King RS;Newmark PA

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损伤后复杂结构的再生需要细胞行为的巨大变化。再生组织启动一个程序,包括多种过程,如伤口愈合、细胞死亡、去分化和干(或祖)细胞增殖;此外,新再生的组织必须将极性和位置特征线索与先前存在的身体结构整合起来。基因敲低方法和基于转基因的谱系和功能分析有助于破译不同动物模型中再生过程的各个方面,以研究再生。
Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regeneration.
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