Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat.
Distinct patterns of neuronal inputs and outputs of the juxtaparaventricular and suprafornical regions of the lateral hypothalamic area in the male rat.
复制标题
DOI：
10.1016/j.brainresrev.2010.02.002
复制
发表时间：
2010-09
影响因子：
--
通讯作者：
Swanson LW
中科院分区：
文献类型：
--
作者：
Hahn JD;Swanson LW
我们已经分析了在高分辨率的下丘脑外侧区（LHAjp）的脑室旁区的神经解剖学连接;作为对照和比较，我们还进行了初步分析附近的LHA区域，背侧的穹窿，即LHA穹窿上区（LHAs）。这些LHA区域的连接，揭示了共注射跟踪技术，涉及逆行（霍乱毒素B亚基）和顺行（菜豆leucoagglutinin）示踪剂。LHAjp和LHA一起连接大脑和脑脊液干的几乎每个主要部分，但它们的连接轮廓明显不同。简单地说，LHAjp的连接表明可能在防御行为的调制中起主要作用; LHAs在摄食行为的调制中起作用。然而，LHAjp和LHA与这些行为的潜在调节的关系，如它们的神经解剖学连接所指示的，似乎是高度整合的，因为它包括共同决定行为的神经系统的每个主要功能分区，即，认知、状态、感觉和运动。此外，尽管针对每个区域指示了关于特定行为模式的主要角色，但是也指示了行为的模式间调制。总之，LHAjp和LHAs的外在联系（就我们所描述的而言）表明，这些区域具有深刻的整合作用，它们可能参与精心设计的行为剧目的协调调节。
We have analyzed at high resolution the neuroanatomical connections of the juxtaparaventricular region of the lateral hypothalamic area (LHAjp); as a control and comparison to this we also performed a preliminary analysis of a nearby LHA region that is dorsal to the fornix, namely the LHA suprafornical region (LHAs). The connections of these LHA regions were revealed with a coinjection tract-tracing technique involving a retrograde (cholera toxin B subunit) and anterograde (Phaseolus vulgaris leucoagglutinin) tracer. The LHAjp and LHAs together connect with almost every major division of the cerebrum and cerebrospinal trunk, but their connection profiles are markedly different and distinct. In simple terms the connections of the LHAjp indicate a possible primary role in the modulation of defensive behavior; for the LHAs a role in the modulation of ingestive behavior is suggested. However, the relation of the LHAjp and LHAs to potential modulation of these behaviors, as indicated by their neuroanatomical connections, appears to be highly integrative as it includes each of the major functional divisions of the nervous system that together determine behavior, i.e., cognitive, state, sensory, and motor. Furthermore, although a primary role is indicated for each region with respect to a particular mode of behavior, inter-mode modulation of behavior is also indicated. In summary, the extrinsic connections of the LHAjp and LHAs (so far as we have described them) suggest that these regions have a profoundly integrative role in which they may participate in the orchestrated modulation of elaborate behavioral repertoires.
登录
查看更多内容
影响因子：
5.5
作者：
Alam, MN;Gong, H;Szymusiak, R
通讯作者：
Szymusiak, R
影响因子：
2.7
作者：
BANDLER, R;DEPAULIS, A;VERGNES, M
通讯作者：
VERGNES, M
影响因子：
3.5
作者：
Bassant, MH;Poindessous-Jazat, F
通讯作者：
Poindessous-Jazat, F
影响因子：
56.9
作者：
Bechara, A;Damasio, H;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
3.3
作者：
BEITZ, AJ
通讯作者：
BEITZ, AJ