Increases in cortisol are positively associated with gains in encoding and maintenance working memory performance in young men.
Increases in cortisol are positively associated with gains in encoding and maintenance working memory performance in young men.
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DOI：
10.3109/10253890.2013.780236
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Morgan G
中科院分区：
文献类型：
--
作者：
Stauble MR;Thompson LA;Morgan G
过去的研究表明，皮质醇分泌的增加与长期记忆的增强或损害有关，具体取决于所涉及的子过程。然而，工作记忆在皮质醇文献中通常被作为一个统一的系统来研究。本研究试图确定皮质醇的增加是否与工作记忆编码子过程的性能提高呈正相关，以及皮质醇的增加与维护子过程的性能变化是否呈正相关或负相关。 33 名年轻男性（M = 19.4 岁，SD = 0.89）参与了变化检测任务，其中包括仅需要编码的条件和需要编码和维护的条件。为了引发皮质醇反应，参与者在两次任务管理之间完成了特里尔社会压力测试（TSST）。在 TSST (T1) 之前和第二次变化检测任务执行的中间 (T2) 获取心血管测量值和唾液样本，以测量第二次变化检测任务期间对 TSST 的自主神经和皮质醇反应。 T1 和 T2 之间皮质醇的增加与编码（r（32）= 0.503，p = 0.003）和维持（r（32）= 0.463，p = 0.007）性能呈正相关。这是一个新颖的发现，因为之前的研究表明皮质醇对工作记忆有损害作用。皮质醇和工作记忆之间的正相关关系可能在之前的任务中被掩盖了，因为这些任务没有单独检查这些特定的子过程。讨论了皮质醇在应激反应中的有益作用。
Past studies have demonstrated that increases in cortisol secretion are associated with either enhancements or impairments of long-term memory, depending on the subprocess involved. However, working memory is generally studied as a unified system within the cortisol literature. The present study sought to determine if cortisol increases are positively associated with increases in performance in the encoding subprocess of working memory, and whether increases are positively or negatively associated with performance changes in the maintenance subprocess. Thirty-three young men (M = 19.4 years, SD = 0.89) participated in a change detection task, consisting of a condition requiring encoding only and a condition requiring both encoding and maintenance. To elicit a cortisol response, participants completed the Trier Social Stress Test (TSST) between two administrations of the task. Cardiovascular measurements and saliva samples were obtained before the TSST (T1), and mid-way between blocks of the second administration of the change detection task (T2), to measure autonomic and cortisol responses to the TSST evident during the second change detection task. Cortisol increases between T1 and T2 were positively correlated with both encoding (r(32) = 0.503, p = 0.003) and maintenance (r(32) = 0.463, p = 0.007) performance. This is a novel finding as previous studies have shown an impairing effect of cortisol on working memory. The positive relation between cortisol and working memory has likely been obscured in previous tasks, which did not examine these specific subprocesses in isolation from each other. The beneficial role of cortisol in the stress response is discussed.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1073/pnas.93.24.13468
发表时间：
1996-11-26
影响因子：
11.1
作者：
Baddeley, A
通讯作者：
Baddeley, A
影响因子：
4.1
作者：
BADDELEY, A;LEWIS, V;THOMSON, N
通讯作者：
THOMSON, N
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH
影响因子：
56.9
作者：
Brewer, JB;Zhao, Z;Gabrieli, JDE
通讯作者：
Gabrieli, JDE