Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response.
Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response.
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DOI：
10.3389/fncel.2022.851500
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发表时间：
2022
影响因子：
5.3
通讯作者：
Tsai TH
中科院分区：
文献类型：
--
作者：
Bao J;Jegede SL;Hawks JW;Dade B;Guan Q;Middaugh S;Qiu Z;Levina A;Tsai TH
声诱发复合电位被称为听觉脑干反应（ABR），它代表了异质听觉神经元群对声音刺激的反应，通常用于基于波幅和潜伏期的临床诊断。然而，最近ABR用于检测人耳蜗突触病变的结果不一致，主要是由于ABR波1振幅的高变异性。在这里，我们不是关注ABR波1的振幅，而是评估ABR波曲率在检测耳蜗突触丢失中的应用。我们首先比较了四种使用模拟ABR波的曲率量化方法，并确定了使用五个数据点的三次样条法可以产生最准确的量化。接下来，我们用耳蜗突触病小鼠模型的ABR数据来评估这种量化方法。数据清楚地表明，与振幅和潜伏期测量相比，曲率测量在识别小鼠耳蜗突触丢失方面更为敏感和一致。我们在不同的中耳炎小鼠模型中进一步测试了这种曲率方法。中耳炎中耳感染引起的曲度曲线变化与耳蜗突触病小鼠的曲度曲线不同。因此，我们的研究表明，曲率量化可以用来解决当前的ABR变异性问题，并可能导致在听力障碍的临床诊断中的其他应用。
The sound-evoked electrical compound potential known as auditory brainstem response (ABR) represents the firing of a heterogenous population of auditory neurons in response to sound stimuli, and is often used for clinical diagnosis based on wave amplitude and latency. However, recent ABR applications to detect human cochlear synaptopathy have led to inconsistent results, mainly due to the high variability of ABR wave-1 amplitude. Here, rather than focusing on the amplitude of ABR wave 1, we evaluated the use of ABR wave curvature to detect cochlear synaptic loss. We first compared four curvature quantification methods using simulated ABR waves, and identified that the cubic spline method using five data points produced the most accurate quantification. We next evaluated this quantification method with ABR data from an established mouse model with cochlear synaptopathy. The data clearly demonstrated that curvature measurement is more sensitive and consistent in identifying cochlear synaptic loss in mice compared to the amplitude and latency measurements. We further tested this curvature method in a different mouse model presenting with otitis media. The change in curvature profile due to middle ear infection in otitis media is different from the profile of mice with cochlear synaptopathy. Thus, our study suggests that curvature quantification can be used to address the current ABR variability issue, and may lead to additional applications in the clinic diagnosis of hearing disorders.
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DOI：
10.1111/j.1365-2613.2009.00677.x
发表时间：
2009-10
影响因子：
3
作者：
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影响因子：
2.4
作者：
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DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
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