Otitis media in a mouse model for Down syndrome.
Otitis media in a mouse model for Down syndrome.
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唐氏综合症小鼠模型中的中耳炎。
DOI：
10.1111/j.1365-2613.2009.00677.x
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发表时间：
2009-10
影响因子：
3
通讯作者：
Zheng QY
中科院分区：
文献类型：
--
作者：
Han F;Yu H;Zhang J;Tian C;Schmidt C;Nava C;Davisson MT;Zheng QY
Ts65Dn小鼠具有许多人类唐氏综合症的表型特征。在这里，我们报告了以中耳积液和听力损失为特征的中耳炎在Ts65Dn小鼠中的流行。在接受测试的53只Ts65Dn小鼠中，81.1%的小鼠至少一只耳朵对至少一个刺激频率(滴答声、8 kHz、16 khz和32 khz)有较高的听觉诱发脑干反应(ABR)阈值。ABR阈值是可变的，从2到7个月龄，没有随年龄增加的趋势。对3-4月龄小鼠的病理观察显示，15只Ts65Dn小鼠中有11只出现中耳积液，但仅在11只野生型小鼠中有2只出现中耳积液。每只小鼠的积液在体积和炎细胞含量上都有很大的不同。与野生型对照相比，Ts65Dn小鼠中耳粘膜普遍增厚，中耳腔上皮内杯状细胞密度较高。在Ts65Dn小鼠身上也发现了对人类具有重要致病性的细菌。这是Ts65Dn小鼠中耳炎作为人类唐氏综合症模型的第一次报告。
The Ts65Dn mouse shares many phenotypic characteristics of human Down syndrome. Here, we report that otitis media, characterized by effusion in the middle ear and hearing loss, was prevalent in Ts65Dn mice. Of the 53 Ts65Dn mice tested, 81.1% had high auditory-evoked brainstem response (ABR) thresholds for at least one of the stimulus frequencies (click, 8 kHz, 16 kHz and 32 kHz), in at least one ear. The ABR thresholds were variable and showed no tendency toward increase with age, from 2 to 7 months of age. Observation of pathology in mice, aged 3–4 months, revealed middle ear effusion in 11 of 15 Ts65Dn mice examined, but only in two of 11 wild-type mice. The effusion in each mouse varied substantially in volume and inflammatory cell content. The middle ear mucosae were generally thickened and goblet cells were distributed with higher density in the epithelium of the middle ear cavity of Ts65Dn mice as compared with those of wild-type controls. Bacteria of pathogenic importance to humans also were identified in the Ts65Dn mice. This is the first report of otitis media in the Ts65Dn mouse as a model characteristic of human Down syndrome.
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DOI：
10.1016/s0165-5876(98)00106-2
发表时间：
1998-10-15
影响因子：
1.5
作者：
Hassmann, E;Skotnicka, B;Musiatowicz, M
通讯作者：
Musiatowicz, M
影响因子：
2.7
作者：
Hunter, CL;Bimonte, HA;Granholm, ACE
通讯作者：
Granholm, ACE
影响因子：
1.4
作者：
IGARASHI, M;TAKAHASHI, M;JOHNSON, PE
通讯作者：
JOHNSON, PE
影响因子：
1.7
作者：
Kanamori, G;Witter, M;Williams-Smith, L
通讯作者：
Williams-Smith, L
影响因子：
1.4
作者：
Macarthur, Carol J.;Pillers, De-Ann M.;Trune, Dennis R.
通讯作者：
Trune, Dennis R.