Mammalian and Fish Gelatin Methacryloyl-Alginate Interpenetrating Polymer Network Hydrogels for Tissue Engineering.
Mammalian and Fish Gelatin Methacryloyl-Alginate Interpenetrating Polymer Network Hydrogels for Tissue Engineering.
复制标题
DOI：
10.1021/acsomega.1c01806
复制
发表时间：
2021-07-13
期刊：
影响因子：
4.1
通讯作者：
Lee MH
中科院分区：
文献类型：
--
作者：
Ma C;Choi JB;Jang YS;Kim SY;Bae TS;Kim YK;Park JM;Lee MH
甲基丙烯酰明胶（GelMA）是一种广泛研究的组织工程生物材料。大多数研究集中在哺乳动物明胶，但某些因素，如哺乳动物疾病和饮食限制，限制了哺乳动物明胶的使用。因此，近年来，鱼胶作为替代材料受到了广泛关注。为了开发具有优异性能的广泛适用的水凝胶，合成了互穿聚合物网络（IPN）水凝胶，因为IPN水凝胶由至少两种不同的水凝胶组分组成以联合收割机结合它们的优点。本研究以A型明胶和鱼明胶为原料制备明胶微球，并将明胶微球与海藻酸钠合成互穿网络水凝胶。GelMA单网络水凝胶用作对照组。在合成IPN水凝胶后，A型水凝胶和鱼型水凝胶的有利机械性能得到改善。A型和鱼IPN水凝胶表现出不同的机械性能（机械强度，溶胀比，降解率）和不同的横截面形态，因为在鱼IPN水凝胶的机械增强程度小于在A型，但是，细胞的生物相容性没有显着差异。因此，这些研究结果可以作为参考，为未来的研究时，选择GelMA作为组织工程的生物材料。
Gelatin methacryloyl (GelMA) has been widely studied as a biomaterial for tissue engineering. Most studies focus on mammalian gelatin, but certain factors, such as mammalian diseases and diet restrictions, limit the use of mammalian gelatin. Thus, fish gelatin has received much attention as a substitute material in recent years. To develop a broadly applicable hydrogel with excellent properties, an interpenetrating polymer network (IPN) hydrogel was synthesized, since IPN hydrogels consist of at least two different hydrogel components to combine their advantages. In this study, we prepared GelMA using type A and fish gelatin and then synthesized IPN hydrogels using GelMA with alginate. GelMA single-network hydrogels were used as a control group. The favorable mechanical properties of type A and fish hydrogels improved after the synthesis of the IPN hydrogels. Type A and fish IPN hydrogels showed different mechanical properties (mechanical strength, swelling ratio, and degradation rate) and different cross-sectional morphologies, since the degree of mechanical enhancement in fish IPN hydrogels was less than that in type A; however, the cell biocompatibilities were not significantly different. Therefore, these findings could serve as a reference for future studies when selecting GelMA as a biological material for tissue engineering.
登录
查看更多内容
影响因子：
5
作者：
Kwon, Song;Lee, Seunghun S.;Hwang, Nathaniel S.
通讯作者：
Hwang, Nathaniel S.
影响因子：
7
作者：
Hoch, Eva;Hirth, Thomas;Borchers, Kirsten
通讯作者：
Borchers, Kirsten
影响因子：
9.7
作者：
Huang CC;Kang M;Shirazi S;Lu Y;Cooper LF;Gajendrareddy P;Ravindran S
通讯作者：
Ravindran S
影响因子：
3.7
作者：
Chiu YC;Kocagöz S;Larson JC;Brey EM
通讯作者：
Brey EM
影响因子：
14
作者：
Koshy, Sandeep T.;Ferrante, Thomas C.;Lewin, Sarah A.;Mooney, David J.
通讯作者：
Mooney, David J.