Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants.
Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants.
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DOI：
10.1017/jns.2021.56
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发表时间：
2021
影响因子：
2.5
通讯作者：
Sacks FM
中科院分区：
文献类型：
--
作者：
Liu X;Dhana K;Furtado JD;Agarwal P;Aggarwal NT;Tangney C;Laranjo N;Carey V;Barnes LL;Sacks FM
越来越多的证据表明水果和蔬菜的消费与认知功能之间存在联系。然而，缺乏针对这种关系背后的营养素的研究。我们的目的是研究因饮食不理想而面临认知能力下降风险的人群中血浆营养素与认知能力之间的关系。地中海-DASH 神经退行性延迟干预 (MIND) 试验是一项随机对照干预措施，旨在检查 MIND 饮食对预防认知能力下降的效果。主要结果是全局认知。使用多元线性模型来研究血液营养素与整体和/或特定领域认知之间的关联。该模型根据年龄、性别、教育程度、研究地点、吸烟状况、认知活动和体力活动进行了调整。高血浆 α-胡萝卜素与更好的整体认知能力相关。与最低三分位数的个体相比，血浆 α-胡萝卜素最高三分位数的参与者的总体认知 z 得分更高，为 0⋅17 (P < 0⋅002)。循环 α-胡萝卜素水平也与较高的语义记忆得分相关（趋势 P 为 0⋅007）。叶黄素和玉米黄质（组合）与较高的语义记忆得分呈正相关（趋势 P 为 0⋅009）。我们的研究表明，在有认知能力下降风险的美国人群中，血液中较高的 α-胡萝卜素水平与较高的整体认知得分相关。血液中较高的α-胡萝卜素水平反映出水果、其他类型蔬菜的摄入量较多，而黄油、人造黄油和肉类的摄入量较少。叶黄素和玉米黄质的循环水平较高反映了水果、绿叶蔬菜、其他蔬菜和奶酪摄入量较高，油炸食品摄入量较低的饮食模式。血液中的客观营养标记物可以更好地表征饮食摄入量，这可能有助于实施量身定制的饮食干预措施以预防认知能力下降。
There is emerging evidence linking fruit and vegetable consumption and cognitive function. However, studies focusing on the nutrients underlying this relationship are lacking. We aim to examine the association between plasma nutrients and cognition in a population at risk for cognitive decline with a suboptimal diet. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) trial is a randomized controlled intervention that examines the effects of the MIND diet to prevent cognitive decline. The primary outcome is global cognition. A multivariate linear model was used to investigate the association between blood nutrients and global and/or domain-specific cognition. The model was adjusted for age, sex, education, study site, smoking status, cognitive activities and physical activities. High plasma α-carotene was associated with better global cognition. Participants in the highest tertile of plasma α-carotene had a higher global cognition z score of 0⋅17 when compared with individuals in the lowest tertile (P 0⋅002). Circulating α-carotene levels were also associated with higher semantic memory scores (P for trend 0⋅007). Lutein and zeaxanthin (combined) was positively associated with higher semantic memory scores (P for trend 0⋅009). Our study demonstrated that higher α-carotene levels in blood were associated with higher global cognition scores in a US population at risk for cognitive decline. The higher α-carotene levels in blood reflected greater intakes of fruits, other types of vegetables and lesser intakes of butter and margarine and meat. The higher circulating levels of lutein plus zeaxanthin reflected a dietary pattern with high intakes of fruits, green leafy, other vegetables and cheese, and low consumption of fried foods. Objective nutrient markers in the blood can better characterize dietary intake, which may facilitate the implementation of a tailored dietary intervention for the prevention of cognitive decline.
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