Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp.
Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp.
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DOI：
10.1155/2015/670437
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发表时间：
2015
影响因子：
4.1
通讯作者：
Su J
中科院分区：
文献类型：
--
作者：
Rao Y;Su J
过去几十年来，全球水产养殖的鱼类产量迅速增长，草鱼所占份额最大。然而，草鱼呼肠孤病毒（GCRV）引起的出血病给草鱼养殖业造成了巨大的损失。在过去的几年中，分子生物学和细胞生物学技术的发展促进了对病原体和免疫系统的理解的重大进展。以刺激鱼类免疫系统为基础的免疫预防也取得了一定的成果。本文综述了近年来GCRV的基础研究、病毒核酸传感器、高迁移率族蛋白（HMGBs）、模式识别受体（PRRs）、Toll样受体（TLR）和视黄酸诱导基因I（RIG-I-）样受体（RLR）;由PRRs介导的I型干扰素（IFN-I）和IFN刺激基因（ISG）激活的信号级联诱导的抗病毒免疫应答。本文还指出了分子遗传标记的潜在应用。此外，作者还讨论了目前的预防和治疗策略（疫苗，RNAi和预防药物），并强调了天然免疫在长期控制草鱼出血病中的重要性。
Global fish production from aquaculture has rapidly grown over the past decades, and grass carp shares the largest portion. However, hemorrhagic disease caused by grass carp reovirus (GCRV) results in tremendous loss of grass carp (Ctenopharyngodon idella) industry. During the past years, development of molecular biology and cellular biology technologies has promoted significant advances in the understanding of the pathogen and the immune system. Immunoprophylaxis based on stimulation of the immune system of fish has also got some achievements. In this review, authors summarize the recent progresses in basic researches on GCRV; viral nucleic acid sensors, high-mobility group box proteins (HMGBs); pattern recognition receptors (PRRs), Toll-like receptors (TLRs) and retinoic acid inducible gene I- (RIG-I-) like receptors (RLRs); antiviral immune responses induced by PRRs-mediated signaling cascades of type I interferon (IFN-I) and IFN-stimulated genes (ISGs) activation. The present review also notices the potential applications of molecule genetic markers. Additionally, authors discuss the current preventive and therapeutic strategies (vaccines, RNAi, and prevention medicine) and highlight the importance of innate immunity in long term control for grass carp hemorrhagic disease.
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影响因子：
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作者：
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