Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.
Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder.
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DOI：
10.1016/j.biopsych.2011.01.035
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发表时间：
2011-09-01
影响因子：
10.6
通讯作者：
Neylan, Thomas C.
中科院分区：
文献类型：
--
作者：
O'Donovan, Aoife;Epel, Elissa;Lin, Jue;Wolkowitz, Owen;Cohen, Beth;Maguen, Shira;Metzler, Thomas;Lenoci, Maryann;Blackburn, Elizabeth;Neylan, Thomas C.
创伤后应激障碍（PTSD）与年龄相关疾病和早期死亡的风险增加有关。生物老化的加速可能导致这种风险增加。为了进行研究，我们评估了患有和不患有PTSD的男性和女性的白细胞端粒长度（LTL），这是一种新兴的生物学年龄标志物。我们还研究了童年创伤，创伤后应激障碍和短期LTL的危险因素，作为一个潜在的贡献者短期LTL的创伤后应激障碍。参与者包括43名患有慢性PTSD的成年人（n=18，有多种类型的儿童创伤）和47名对照组（无多种类型的儿童创伤）（M年龄= 30.55，SD = 7.44）。排除标准包括身体疾病、药物使用、肥胖、酒精或药物滥用和怀孕。进行了结构化的临床访谈，以评估创伤后应激障碍和其他精神疾病和儿童创伤暴露。用定量聚合酶链反应测定LTL。正如预测的那样，PTSD参与者的年龄调整LTL比对照组短。暴露于童年创伤也与LTL短。事实上，童年创伤似乎可以解释PTSD组LTL的差异;只有PTSD和暴露于多种童年创伤的参与者的LTL显著短于对照组。儿童创伤与PTSD患者的短LTL相关。长期暴露于童年创伤的心理生物学后遗症可能会增加PTSD和短期LTL的风险。因此，童年时期遭受创伤的持久心理影响可能伴随着分子水平上同样持久的变化。
Post-traumatic stress disorder (PTSD) is associated with increased risk for age-related diseases and early mortality. An accelerated rate of biological aging could contribute to this increased risk. To investigate, we assessed leukocyte telomere length (LTL), an emerging marker of biological age, in men and women with and without PTSD. We also examined childhood trauma, a risk factor for both PTSD and short LTL, as a potential contributor to short LTL in PTSD. Participants included 43 adults with chronic PTSD (n=18 with multiple categories of childhood trauma) and 47 controls (none with multiple categories of childhood trauma) (M age = 30.55, SD = 7.44). Exclusion criteria included physical illness, medication use, obesity, alcohol or substance abuse, and pregnancy. Structured clinical interviews were conducted to assess PTSD and other psychiatric disorders and childhood trauma exposure. LTL was measured with quantitative polymerase chain reaction. As predicted, participants with PTSD had shorter age-adjusted LTL than controls. Exposure to childhood trauma was also associated with short LTL. In fact, childhood trauma appeared to account for the PTSD group difference in LTL; only participants with PTSD and exposure to multiple categories of childhood trauma had significantly shorter LTL than controls. Childhood trauma is associated with short LTL in individuals with PTSD. Chronic exposure to the psychobiological sequelae of childhood trauma could increase risk for PTSD and short LTL. Thus, the lasting psychological impact of exposure to trauma in childhood may be accompanied by equally enduring changes at the molecular level.
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影响因子：
4.2
作者：
DUREL, LA;CARVER, CS;SCHNEIDERMAN, N
通讯作者：
SCHNEIDERMAN, N
影响因子：
7.4
作者：
Hoge, E. A.;Brandstetter, K.;Simon, N. M.
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Simon, N. M.
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
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作者：
Briere, John;Kaltman, Stacey;Green, Bonnie L.
通讯作者：
Green, Bonnie L.
影响因子：
5
作者：
Fitzpatrick, Annette L.;Kronmal, Richard A.;Aviv, Abraham
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Aviv, Abraham