Cutaneous lewisite exposure causes acute lung injury.
Cutaneous lewisite exposure causes acute lung injury.
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DOI：
10.1111/nyas.14346
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发表时间：
2020-11
影响因子：
5.2
通讯作者：
Ahmad A
中科院分区：
文献类型：
--
作者：
Manzoor S;Mariappan N;Zafar I;Wei CC;Ahmad A;Surolia R;Foote JB;Agarwal A;Ahmad S;Athar M;Antony VB;Ahmad A
路易氏剂是一种强起泡剂和化学战剂。由于快速透皮吸收，皮肤暴露于路易氏剂也可引起严重的全身性损伤。将路易氏剂（2.5、5.0和7.5 mg/kg）应用于Ptch 1 +/−/SKH-1小鼠的皮肤，并在24小时后评估急性肺损伤（ALI）。动脉血气测量显示，高碳酸血症和低氧血症的路易氏暴露组。肺组织的组织学评价显示，促炎性中性粒细胞水平升高，指示损伤的结构变化呈剂量依赖性增加。细胞因子表达的改变也证实了炎症的增加，包括IL-33的增加，并且在肺组织中观察到CXCL 1、CXCL 5和GCSF的剂量依赖性升高。在暴露于路易氏剂的动物的支气管肺泡灌洗液中，存在损伤相关分子模式分子HMGB 1的显著增加，以及升高的CXCL 1和CXCL 5，这与中性粒细胞流入肺一致。全血细胞分析显示嗜酸性粒细胞增多和中性粒细胞/淋巴细胞比率改变，这是路易氏剂暴露的结果。平均血小板体积和红细胞分布宽度，肺损伤的预测因子，也增加了路易氏剂组。这些数据表明，皮肤路易氏剂暴露导致ALI，并可能导致暴露人群的死亡率。
Lewisite is a strong vesicating and chemical warfare agent. Due to rapid transdermal absorption, cutaneous exposure to Lewisite can also elicit severe systemic injury. Lewisite (2.5, 5.0 and 7.5 mg/kg) was applied to skin of Ptch1+/−/SKH-1 mice and acute lung injury (ALI) was assessed after 24h. Arterial blood-gas measurements showed hypercapnia and hypoxemia in the Lewisite-exposed group. Histological evaluation of lung tissue revealed increased levels of proinflammatory neutrophils and a dose-dependent increase in structural changes indicative of injury. Increased inflammation was also confirmed by the altered cytokines expression, including increased IL-33 and a dose-dependent elevation of CXCL1, CXCL5 and GCSF was observed in the lung tissue. In the bronchoalveolar lavage fluid of Lewisite-exposed animals, there was significant increase in HMGB1, a damage associated molecular pattern molecule, as well as elevated CXCL1 and CXCL5, which coincided with neutrophils influx to the lung.. Complete blood cell analysis revealed eosinophilia and altered neutrophil/lymphocyte ratios, as a consequence of Lewisite exposure. Mean platelet volume and RBC distribution width, predictors of lung injury, were also increased in the Lewisite group. These data demonstrate that cutaneous Lewisite exposure causes ALI and may contribute to mortality in exposed populations.
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影响因子：
81.5
作者：
Matthay, Michael A.;Zemans, Rachel L.;Calfee, Carolyn S.
通讯作者：
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影响因子：
5.2
作者：
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通讯作者：
Mantell LL
DOI：
10.1165/rcmb.2009-0210st
发表时间：
2011-05-01
影响因子：
6.4
作者：
Matute-Bello, Gustavo;Downey, Gregory;Villar, Jesus
通讯作者：
Villar, Jesus