Quantitative measurement of macromolecular tissue properties in white and gray matter in healthy aging and amnestic MCI.
Quantitative measurement of macromolecular tissue properties in white and gray matter in healthy aging and amnestic MCI.
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DOI：
10.1016/j.neuroimage.2021.118161
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发表时间：
2021-08-15
期刊：
影响因子：
5.7
通讯作者：
Hosseini SMH
中科院分区：
文献类型：
--
作者：
Gozdas E;Fingerhut H;Wu H;Bruno JL;Dacorro L;Jo B;O'Hara R;Reiss AL;Hosseini SMH
健康和病理性衰老通过复杂的过程影响大脑微观结构。辨别这些过程需要对脑组织的特定生物学特性敏感的测量。我们将一种新的定量R1测量与多壳扩散加权成像相结合，以绘制健康老年人和健忘轻度认知障碍（aMCI）患者沿主要白质束的大分子组织体积（MTV）的年龄相关变化。在健康老龄化中，关联束的MTV减少与年龄增长有关，与记忆表现相关，并将aMCI与对照组区分开来。我们还使用定量R1测量绘制了灰质组织特性的变化。我们记录了随着年龄的增长，整个皮层R1普遍下降，与对照相比，与情景记忆有关的区域aMCI中R1下降。我们的数据首次描述了aMCI中沿主要白质束的MTV损失，并表明qMRI是一种灵敏的方法，可以检测到传统MRI和弥散测量无法检测到的白质和灰质组织的细微变性。
Healthy and pathological aging influence brain microstructure via complex processes. Discerning these processes require measurements that are sensitive to specific biological properties of brain tissue. We integrated a novel quantitative R1 measure with multi-shell diffusion weighted imaging to map age-associated changes in macromolecular tissue volume (MTV) along major white matter tracts in healthy older adults and patients with amnestic Mild Cognitive Impairment (aMCI). Reduced MTV in association tracts was associated with older age in healthy aging, was correlated with memory performance, and distinguished aMCI from controls. We also mapped changes in gray matter tissue properties using quantitative R1 measurements. We documented a widespread decrease in R1 with advancing age across cortex and decreased R1 in aMCI compared with controls in regions implicated in episodic memory. Our data are the first to characterize MTV loss along major white matter tracts in aMCI and suggest that qMRI is a sensitive measure for detecting subtle degeneration of white and gray matter tissue that cannot be detected by conventional MRI and diffusion measures.
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