Comparison of endoscopic features of early-stage squamous cell lung cancer and histological findings.
Comparison of endoscopic features of early-stage squamous cell lung cancer and histological findings.
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DOI：
10.1038/sj.bjc.6690540
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发表时间：
1999-07
影响因子：
8.8
通讯作者：
Watanabe, Y
中科院分区：
文献类型：
--
作者：
Konaka, C;Hirano, T;Kato, H;Furuse, K;Takada, M;Saito, Y;Monden, Y;Matsui, E;Watanabe, Y
关键词：
1984年至1993年，在七个参与研究的机构中，对70例早期中央型鳞状细胞癌进行了手术治疗。我们将早期中央型鳞状细胞癌的内视镜特征分为三种类型（肥大型、结节型及息肉型）。手术后，我们研究内镜下的特点和浅表范围和深度的癌浸润的组织病理学研究的基础上的手术标本的面积之间的关系。在66.7%的肥大型病变中，癌细胞没有侵入软骨层，只有4.8%的这种类型的肿瘤浸润超过支气管软骨。另一方面，少数结节和息肉型病例显示原位癌或癌从上皮下层浸润到肌肉层，在约20%的这些类型中，我们观察到癌浸润超过软骨层，这不适合光动力治疗。此外，关于最大尺寸，35处病变中的24处（68.6%）最大尺寸小于10 mm，被评价为肌肉层内的原位癌或微侵袭性肿瘤。结论早期中央型肺癌的内镜表现可为治疗方案的制定提供依据。© 1999癌症研究运动
Seventy cases with early-stage central-type squamous cell carcinoma were treated surgically between 1984 and 1993 in seven participating institutes. We classified endoscopic features of early-stage central-type squamous cell carcinoma into three types (hypertrophic type, nodular type and polypoid type). After surgery we investigated the relationship between endoscopic features and both the area of superficial extent and depth of carcinoma invasion based on histopathological investigations of the surgical specimens. In 66.7% of the hypertrophic type lesions cancer cells did not invade into the cartilaginous layer, and only 4.8% of this type showed tumour invasion beyond the bronchial cartilage. On the other hand, a few nodular and polypoid type cases showed in-situ carcinoma or carcinoma with invasion from the subepithelial layer to the muscle layer, and in approximately 20% the these types we observed carcinoma invasion beyond the cartilaginous layer, which was not suitable for photodynamic therapy. Also, concerning the greatest dimension 24 out of 35 lesions (68.6%) less than 10 mm in the greatest dimension were evaluated as either in-situ carcinoma or micro-invasive tumour within the muscle layer. The endoscopic features can provide a basis for the determination of therapeutic strategy in early-stage central-type lung cancer. © 1999 Cancer Research Campaign
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影响因子：
10
作者：
HURTER, T;HANRATH, P
通讯作者：
HANRATH, P
DOI：
10.1016/s0022-5223(19)33775-4
发表时间：
1993-06-01
影响因子：
6
作者：
LAM, S;MACAULAY, C;PALCIC, B
通讯作者：
PALCIC, B
影响因子：
1.3
作者：
MATSUDA, M;HORAI, T;TATEISHI, R
通讯作者：
TATEISHI, R
DOI：
10.1016/0360-3016(95)02390-9
发表时间：
1996-03-15
影响因子：
7
作者：
Saito, M;Yokoyama, A;Fujimori, K
通讯作者：
Fujimori, K
影响因子：
1.5
作者：
SCHUDER, G;ISRINGHAUS, H;SYBRECHT, GW
通讯作者：
SYBRECHT, GW