Ambient air pollution and the risk of pregnancy loss: a prospective cohort study.
Ambient air pollution and the risk of pregnancy loss: a prospective cohort study.
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DOI：
10.1016/j.fertnstert.2017.09.037
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发表时间：
2018-01
影响因子：
6.7
通讯作者：
Mendola P
中科院分区：
文献类型：
--
作者：
Ha S;Sundaram R;Buck Louis GM;Nobles C;Seeni I;Sherman S;Mendola P
估计流产与常见空气污染物暴露之间的关联。环境空气污染暴露与不良妊娠结局有关，但很少有研究调查其与流产的关系。前瞻性队列研究 美国密歇根州和德克萨斯州进行了一项多中心前瞻性队列研究，对 344 例单胎妊娠进行了研究，并制定了详细的排卵和妊娠检测方案。无 发生流产的时间（从排卵开始） 流产的发生率为 28% (n=98)。使用修改后的社区多尺度空气质量模型估算了妇女住所的污染物水平，并计算了过去两周（急性）和整个怀孕期间（慢性）的平均值。调整后的 Cox 比例风险模型显示，整个妊娠期间平均臭氧 [HR: 1.12 (95% CI: 1.07–1.17)] 和颗粒物 <2.5 微米 [HR: 1.13 (1.03–1.24)] 浓度的四分位数范围增加与更快的流产时间相关。硫酸盐化合物似乎也会增加风险[HR：1.58 (1.07–2.34)]。过去两周的暴露与损失无关。在试图怀孕的夫妇的前瞻性队列中，我们发现证据表明，整个怀孕期间暴露于空气污染与损失有关，但描绘脆弱性加剧的特定时期有待更大规模的孕前队列研究，每天测量空气质量。
To estimate the association of pregnancy loss with common air pollutant exposure. Ambient air pollution exposure has been linked to adverse pregnancy outcomes, but few studies have investigated its relationship with pregnancy loss. Prospective cohort study Michigan and Texas, USA 344 singleton pregnancies in a multisite prospective cohort study with detailed protocols for ovulation and pregnancy testing. None Timing of incident pregnancy loss (from ovulation) The incidence of pregnancy loss was 28% (n=98). Pollutant levels at women’s residences were estimated using modified Community Multiscale Air Quality models and averaged over the last two weeks (acute) and the whole pregnancy (chronic). Adjusted Cox proportional hazards models showed that an interquartile range increase in average whole pregnancy ozone [HR: 1.12 (95% CI: 1.07–1.17)] and particulate matter <2.5 microns [HR: 1.13 (1.03–1.24)] concentrations were associated with faster time to pregnancy loss. Sulfate compounds also appeared to increase risk [HR: 1.58 (1.07–2.34)]. Last two weeks exposures were not associated with loss. In a prospective cohort of couples trying to conceive, we found evidence that exposure to air pollution throughout pregnancy was associated with loss, but delineating specific periods of heightened vulnerability await larger preconception cohort studies with daily measured air quality.
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影响因子：
8.3
作者：
Patel, Molini M.;Chillrud, Steven N.;Deepti, K. C.;Ross, James M.;Kinney, Patrick L.
通讯作者：
Kinney, Patrick L.
中国的环境空气污染与选定的不良怀孕结局之间的关联：系统评价。
DOI：
10.1016/j.scitotenv.2016.11.100
发表时间：
2017-02-01
期刊：
The Science of the total environment
影响因子：
--
作者：
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通讯作者：
Pereira G
影响因子：
3.3
作者：
Bonde, JPE;Hjollund, NHI;Olsen, J
通讯作者：
Olsen, J
影响因子：
5
作者：
Cole, Stephen R.;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
影响因子：
2.2
作者：
DeVries R;Kriebel D;Sama S
通讯作者：
Sama S