Reduced short interval cortical inhibition correlates with atomoxetine response in children with attention-deficit hyperactivity disorder (ADHD).
Reduced short interval cortical inhibition correlates with atomoxetine response in children with attention-deficit hyperactivity disorder (ADHD).
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DOI：
10.1177/0883073813513333
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发表时间：
2014-12
影响因子：
1.9
通讯作者：
Gilbert DL
中科院分区：
文献类型：
--
作者：
Chen TH;Wu SW;Welge JA;Dixon SG;Shahana N;Huddleston DA;Sarvis AR;Sallee FR;Gilbert DL
对注意缺陷多动障碍(ADHD)儿童的临床试验表明，选择性去甲肾上腺素再摄取抑制剂托莫西汀(ATX)的行为反应不同。本研究的目的是确定经颅磁刺激(TMS)诱发的短间隔皮质抑制(SICI)是否可能是预测临床ATX反应的生物标志物，或与临床ATX反应相关。对7-12岁ADHD儿童进行ATX治疗，治疗前和治疗4周后测量TMS-SICI，临床盲法改善。主要分析方法为多变量ANCOVA。基线SICI不能预测临床反应。然而，矛盾的是，在ATX治疗4周后，应答者的平均SICI降低了31.9%，无应答者的SICI增加了6.1%(ANCOVA T41=2.88；p=0.0063)。SICI减少的百分比与ADHD评定量表(ADHDRS)的减少相关(r=.50；p=.0005)。在接受ATX治疗的7-12岁ADHD儿童中，临床症状的改善与运动皮质SICI的减少相关。
Clinical trials in children with Attention Deficit Hyperactivity Disorder (ADHD) show variability in behavioral responses to the selective norepinephrine reuptake inhibitor atomoxetine (ATX). The objective of this study was to determine whether Transcranial Magnetic Stimulation (TMS)-evoked Short Interval Cortical Inhibition (SICI) might be a biomarker predicting, or correlating with, clinical ATX response. At baseline and after 4 weeks of ATX treatment in 7–12 year old children with ADHD, TMS-SICI was measured, blinded to clinical improvement. Primary analysis was by multivariate ANCOVA. Baseline SICI did not predict clinical responses. However, paradoxically, after 4 weeks of ATX, mean SICI was reduced 31.9% in responders and increased 6.1% in non-responders (ANCOVA t41=2.88; p = .0063). Percent reductions in SICI correlated with reductions in ADHD-Rating Scale (ADHDRS) (r = .50; p = .0005). In children ages 7–12 years with ADHD treated with ATX, improvements in clinical symptoms are correlated with reductions in motor cortex SICI.
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影响因子：
2.5
作者：
Moll, GH;Heinrich, H;Rothenberger, A
通讯作者：
Rothenberger, A
影响因子：
1.7
作者：
Nezu, A;Kimura, S;Saito, K
通讯作者：
Saito, K
影响因子：
5.5
作者：
Ilic, TV;Meintzschel, F;Ziemann, U
通讯作者：
Ziemann, U
DOI：
10.1097/01.chi.0000020259.43550.f4
发表时间：
2002-09-01
影响因子：
13.3
作者：
Riddle, MA;Ginsburg, GS;Roper, M
通讯作者：
Roper, M
影响因子：
3.7
作者：
Hoegl T;Heinrich H;Barth W;Lösel F;Moll GH;Kratz O
通讯作者：
Kratz O