Time course analysis of motor excitability in a response inhibition task according to the level of hyperactivity and impulsivity in children with ADHD.
Time course analysis of motor excitability in a response inhibition task according to the level of hyperactivity and impulsivity in children with ADHD.
复制标题
DOI：
10.1371/journal.pone.0046066
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kratz O
中科院分区：
文献类型：
--
作者：
Hoegl T;Heinrich H;Barth W;Lösel F;Moll GH;Kratz O
在被动（静息）状态下通过经颅磁刺激（TMS）测量的运动皮层短间期皮质内抑制（SICI）已被认为是注意力缺陷多动障碍（ADHD）中多动的神经生理学标志。本研究的目的是确定在一个去/不去任务的反应准备，激活和抑制阶段的ADHD儿童，根据多动和冲动的水平。运动诱发电位记录在29个典型的发展中的儿童和43名儿童多动症（细分为两组较高和较低水平的多动/冲动; H/I-高和H/I-低）。在H/I高组，SICI在静息状态和反应准备期间显著降低。尽管这些儿童在抑制反应时能够增加SICI，但与典型发育儿童相比，SICI仍然减少。有趣的是，SICI在休息和反应激活期间是相当的，这可能与他们的运动过度行为。在H/I-low组中，反应激活伴随着SICI的显著降低，表明在快速运动反应的背景下运动控制降低。总之，不同的兴奋性模式，获得了三组允许更好地了解多动症儿童运动皮层内的功能障碍性反应激活和抑制过程。
Short interval intracortical inhibition (SICI) of motor cortex, measured by transcranial magnetic stimulation (TMS) in a passive (resting) condition, has been suggested as a neurophysiological marker of hyperactivity in attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to determine motor excitability in a go/nogo task at stages of response preparation, activation and suppression in children with ADHD, depending on the level of hyperactivity and impulsivity. Motor evoked potentials were recorded in 29 typically developing children and 43 children with ADHD (subdivided in two groups with higher and lower levels of hyperactivity/impulsivity; H/I-high and H/I-low). In the H/I-high group, SICI was markedly reduced in the resting condition and during response preparation. Though these children were able to increase SICI when inhibiting a response, SICI was still reduced compared to typically developing children. Interestingly, SICI at rest and during response activation were comparable, which may be associated with their hypermotoric behaviour. In the H/I-low group, response activation was accompanied by a pronounced decrease of SICI, indicating reduced motor control in the context of a fast motor response. In summary, different excitability patterns were obtained for the three groups allowing a better understanding of dysfunctional response activation and inhibition processes within the motor cortex in children with ADHD.
登录
查看更多内容
影响因子：
4.7
作者：
Boylan, LS;Sackeim, HA
通讯作者：
Sackeim, HA
影响因子：
3.7
作者：
Burle, B;Bonnet, M;Hasbroucq, T
通讯作者：
Hasbroucq, T
影响因子：
2.5
作者：
Buchmann, J.;Gierow, W.;Wolters, A.
通讯作者：
Wolters, A.
影响因子：
10.6
作者：
Buchmann, Johannes;Gierow, Wolfgang;Wolters, Alexander
通讯作者：
Wolters, Alexander
影响因子：
3
作者：
Hoegl, Thomas;Heinrich, Hartmut;Kratz, Oliver
通讯作者：
Kratz, Oliver