Integrating orbitofrontal cortex into prefrontal theory: common processing themes across species and subdivisions.
Integrating orbitofrontal cortex into prefrontal theory: common processing themes across species and subdivisions.
复制标题
将眶额皮层整合到前额理论中：跨物种和细分的常见处理主题。
DOI：
10.1101/lm.39901
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Setlow,B
中科院分区：
文献类型：
--
作者：
Schoenbaum,G;Setlow,B
目前，许多理论强调表征记忆或规则表征作为前额叶功能的标志。灵长类动物背外侧前额叶皮层的神经生理学研究结果表明，这两个功能可能表征前额叶处理。背外侧前额叶皮层的神经元在工作记忆中编码信息，当这些信息与控制任务表现的规则相关时，这些信息就会被呈现出来。在这篇综述中，我们讨论了最近的报告，在灵长类动物和大鼠眶额区的编码表明，这些功能也表征活动的眶额细分的前额叶皮层。这些数据表明：（1）眶额皮层的神经活动将激励者的当前激励值与线索联系起来，而不是代表线索或相关激励者的物理特征;（2）当这种激励信息与指导任务表现的规则相关时，它在眶额皮层中被代表;（3）在工作记忆中，当线索和刺激都不存在时，刺激信息在延迟期间也在眶额皮层中呈现。因此，虽然眶额皮层似乎是唯一专门处理激励或动机信息，它可能被整合到一个更全球性的框架，前额叶功能的特点是表征编码的性能相关的信息。
Currently, many theories highlight either representational memory or rule representation as the hallmark of prefrontal function. Neurophysiological findings in the primate dorsolateral prefrontal cortex indicate that both features may characterize prefrontal processing. Neurons in the dorsolateral prefrontal cortex encode information in working memory, and this information is represented when relevant to the rules governing performance in a task. In this review, we discuss recent reports of encoding in primate and rat orbitofrontal regions indicating that these features also characterize activity in the orbitofrontal subdivision of the prefrontal cortex. These data indicate that (1) neural activity in the orbitofrontal cortex links the current incentive value of reinforcers to cues, rather than representing the physical features of cues or associated reinforcers; (2) this incentive-based information is represented in the orbitofrontal cortex when it is relevant to the rules guiding performance in a task; and (3) incentive information is also represented in the orbitofrontal cortex in working memory during delays when neither the cues nor reinforcers are present. Therefore, although the orbitofrontal cortex appears to be uniquely specialized to process incentive or motivational information, it may be integrated into a more global framework of prefrontal function characterized by representational encoding of performance-relevant information.
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影响因子：
1.9
作者：
T. Otto;H. Eichenbaum
通讯作者：
T. Otto;H. Eichenbaum
DOI：
10.1098/rstb.1996.0138
发表时间：
1996-10-29
影响因子：
6.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
MISHKIN, M
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2.5
作者：
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通讯作者：
GROSS, CG
DOI：
10.1523/jneurosci.10-11-03479.1990
发表时间：
1990-11
期刊：
--
影响因子：
--
作者：
D. Gaffan;Elisabeth A. Murray
通讯作者：
D. Gaffan;Elisabeth A. Murray