Uniform distribution of three Candida albicans microsatellite markers in two French ICU populations supports a lack of nosocomial cross-contamination.
Uniform distribution of three Candida albicans microsatellite markers in two French ICU populations supports a lack of nosocomial cross-contamination.
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两个法国ICU种群中三个白色念珠菌微卫星标记的均匀分布支持缺乏医院的交叉污染。
DOI：
10.1186/1471-2334-6-162
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发表时间：
2006-11-13
影响因子：
3.7
通讯作者：
Bretagne, Stephane
中科院分区：
文献类型：
--
作者：
Eloy, Odile;Marque, Stephanie;Botterel, Francoise;Stephan, Francois;Costa, Jean-Marc;Lasserre, Virginie;Bretagne, Stephane
在重症监护病房（ICU）中，白色念珠菌的医院获得越来越受到关注，了解污染途径与感染控制指南相关。为了分析任何一家医院是否有特定的生态环境，我们对C基因进行了分型。白念珠菌分离的凡尔赛医院（医院A）的ICU，并比较了结果与先前获得的另一个ICU在亨利蒙多医院（医院B）使用三个多态性微卫星标记（PMM）。在36例至少有1例C.白念珠菌中，26人有一个特定的多位点基因型，两个共享一个共同的多位点基因型，和8个最常见的多位点基因型在一般人群中发现。具有常见基因型的患者之间的住院时间间隔相差13至78天，因此支持缺乏直接污染。为了证实这一假设，三个PMM的多位点基因型分布比较两家医院。未观察到统计学显著差异。多重对应分析未显示多位点基因型分布与任何给定医院的相关性。目前的流行病学研究支持这样的结论，即每个患者都有自己的分离株，并且在任何给定的ICU中，医院内传播并不常见。本研究也支持PMM在研究C.白色念珠菌
The nosocomial acquisition of Candida albicans is a growing concern in intensive care units (ICUs) and understanding the route of contamination is relevant for infection control guidelines. To analyze whether there is a specific ecology for any given hospital, we genotyped C. albicans isolates of the ICU of Versailles hospital (Hospital A) and compared the results with those previously obtained in another ICU in Henri Mondor hospital (Hospital B) using three polymorphic microsatellite markers (PMM). Among 36 patients with at least one positive culture for C. albicans, 26 had a specific multilocus genotype, two shared a common multilocus genotype, and 8 had the most common multilocus genotype found in the general population. The time interval between periods of hospitalization between patients with common genotypes differed by 13 to 78 days, thus supporting a lack of direct contamination. To confirm this hypothesis, the multilocus genotypic distributions of the three PMM were compared between the two hospitals. No statistically significant difference was observed. Multiple correspondences analysis did not indicate the association of a multilocus genotypic distribution with any given hospital. The present epidemiological study supports the conclusions that each patient harbours his/her own isolate, and that nosocomial transmission is not common in any given ICU. This study also supports the usefulness and practicability of PMM for studying the epidemiology of C. albicans.
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影响因子：
2.8
作者：
Lott, TJ;Effat, MM
通讯作者：
Effat, MM
影响因子：
9.4
作者：
SCHMID, J;TAY, YP;MCKINNEY, W
通讯作者：
MCKINNEY, W
影响因子：
6.9
作者：
Taylor, BN;Harrer, T;Schröppel, K
通讯作者：
Schröppel, K
影响因子：
120.7
作者：
LEGALL, JR;LEMESHOW, S;SAULNIER, F
通讯作者：
SAULNIER, F
影响因子：
9.4
作者：
Costa, JM;Eloy, O;Bretagne, S
通讯作者：
Bretagne, S