Prediction of pregnancy after frozen-thawed embryo transfer via in vivo intrauterine oxidation-reduction potential measurements: a pilot study.
Prediction of pregnancy after frozen-thawed embryo transfer via in vivo intrauterine oxidation-reduction potential measurements: a pilot study.
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DOI：
10.1002/rmb2.12098
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发表时间：
2018-07
影响因子：
3.4
通讯作者：
Kimura T
中科院分区：
文献类型：
--
作者：
Nakamura H;Hosono T;Taniguchi T;Kumasawa K;Goa S;Ono M;Kimura T
在着床期间，子宫经历许多复杂的、协调的变化，包括由于唾液酸化、硫酸化和岩藻糖基化引起的糖萼的改变。先前的小鼠研究表明，体内子宫内氧化还原电位（ORP）有助于确定子宫内膜的变化，这些变化适合于植入和评估预期的子宫容受性，而体内子宫内pH值则不能。评估了体内子宫内ORP是否可以作为预测女性妊娠的有用参数。对在程序化、母体控制周期中接受冻融单胚胎移植的患者进行了一项前瞻性队列研究。在治疗周期期间，在周期第9 - 10天、孕酮给药前1天和胚胎移植前即刻测量3次体内子宫内ORP。妊娠组在月经出血开始后9 - 10天的体内子宫内ORP量显著低于非妊娠组。宫内ORP作为未受孕预测因子的受试者操作特征曲线分析显示曲线下面积为0.80。体内子宫内ORP可能是预测冻融胚胎移植治疗周期妊娠的有用参数。
During the implantation period, the uterus goes through many complex, orchestrated changes, including alterations of the glycocalyx that are due to sialylation, sulfation, and fucosylation. A previous mouse study showed that the in vivo intrauterine oxidation‐reduction potential (ORP) aided in determining the alterations in the uterine endometrium that are suitable for implantation and for evaluating prospective uterine receptivity, while the in vivo intrauterine pH did not. It was assessed if the in vivo intrauterine ORP could be a useful parameter to predict pregnancy in women. A prospective cohort study was conducted for patients who had received a frozen‐thawed single embryo transfer in a programmed, hormonally controlled cycle. The in vivo intrauterine ORP was measured 3 times during the treatment cycle, at cycle days 9‐10, 1 day before progesterone administration and immediately before the embryo transfer. The amount of in vivo intrauterine ORP at 9‐10 days after the start of menstrual bleeding was significantly lower in the pregnant group than in the non‐pregnant group. A receiver‐operator characteristic curve analysis of the intrauterine ORP as a predictor of non‐conception showed an area under the curve of 0.80. The in vivo intrauterine ORP could be a useful parameter to predict pregnancy for the frozen‐thawed embryo transfer treatment cycle.
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