The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment.
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DOI：
10.1016/j.celrep.2014.02.038
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发表时间：
2014-03-27
期刊：
影响因子：
8.8
通讯作者：
Kuperwasser C
中科院分区：
文献类型：
--
作者：
Skibinski A;Breindel JL;Prat A;Galván P;Smith E;Rolfs A;Gupta PB;LaBaer J;Kuperwasser C
许多组织的谱系定向细胞在诸如伤口愈合和肿瘤发生的背景下表现出实质性的可塑性，但是该过程的调节还不清楚。在这里，我们确定了河马传感器WWTR 1/TAZ的转录因子能够促进乳腺上皮细胞的谱系切换屏幕。TAZ在管腔细胞中的强制表达诱导它们采用基底特征，并且TAZ在基底/肌上皮细胞中的耗尽导致管腔分化。在人类和小鼠组织中，TAZ仅在基底细胞中具有活性，并且在稳态期间对基底细胞维持至关重要。因此，TAZ的缺失影响乳腺发育，导致管腔和基底细胞群的失衡以及分支缺陷。在机制上，TAZ与SWI/SNF复合物的组分相互作用以调节谱系特异性基因表达。总的来说，这些发现揭示了Hippo信号在通过招募染色质重塑复合物确定谱系身份中的新作用。
Lineage-committed cells of many tissues exhibit substantial plasticity in contexts such as wound healing and tumorigenesis, but the regulation of this process is not well understood. Here, we identified the Hippo transducer WWTR1/TAZ in a screen of transcription factors able to prompt lineage switching of mammary epithelial cells. Forced expression of TAZ in luminal cells induces them to adopt basal characteristics, and depletion of TAZ in basal/myoepithelial cells leads to luminal differentiation. In human and mouse tissues, TAZ is active only in basal cells and is critical for basal cell maintenance during homeostasis. Accordingly, loss of TAZ affects mammary gland development, leading to an imbalance of luminal and basal populations as well as branching defects. Mechanistically, TAZ interacts with components of the SWI/SNF complex to modulate lineage-specific gene expression. Collectively, these findings uncover a new role for Hippo signaling in the determination of lineage identity through recruitment of chromatin remodeling complexes.
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影响因子：
64.5
作者：
Rosenbluh J;Nijhawan D;Cox AG;Li X;Neal JT;Schafer EJ;Zack TI;Wang X;Tsherniak A;Schinzel AC;Shao DD;Schumacher SE;Weir BA;Vazquez F;Cowley GS;Root DE;Mesirov JP;Beroukhim R;Kuo CJ;Goessling W;Hahn WC
通讯作者：
Hahn WC
影响因子：
5.9
作者：
Kannan, Nagarajan;Huda, Nazmul;Gilley, David
通讯作者：
Gilley, David
TAZ 促进细胞增殖和上皮间质转化，并受 hippo 通路抑制
影响因子：
5.3
作者：
Lei, Qun-Ying;Zhang, Heng;Guan, Kun-Liang
通讯作者：
Guan, Kun-Liang
影响因子：
2.5
作者：
Gudjonsson, Thorarinn;Adriance, Melissa C.;Bissell, Mina J.
通讯作者：
Bissell, Mina J.
DOI：
10.1073/pnas.1004060107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Chen, Chiao-Lin;Gajewski, Kathleen M.;Halder, Georg
通讯作者：
Halder, Georg