Carnosol: a promising anti-cancer and anti-inflammatory agent.
Carnosol: a promising anti-cancer and anti-inflammatory agent.
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DOI：
10.1016/j.canlet.2011.02.005
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发表时间：
2011-06-01
期刊：
影响因子：
9.7
通讯作者：
Johnson, Jeremy J.
中科院分区：
文献类型：
--
作者：
Johnson, Jeremy J.
地中海饮食，更具体地说，地中海地区某些地区的某些肉类、水果、蔬菜和橄榄油与心血管和糖尿病风险降低有关。最近，一些基于人群的研究发现，选择这些生活方式可以总体降低多种癌症的风险。一项研究特别观察到食用迷迭香、鼠尾草、欧芹和牛至等地中海草药与肺癌之间存在负相关关系。鉴于这些发现，需要探索和鉴定这些草药的抗癌特性并鉴定其中的植物化学物质。特别是一种药物鼠尾草酚，已在前列腺癌、乳腺癌、皮肤癌、白血病和结肠癌中进行了抗癌特性评估，并取得了有希望的结果。这些研究提供的证据表明，鼠尾草酚针对与炎症和癌症相关的多种失调途径，包括核因子 kappa B (NFκB)、细胞凋亡相关蛋白、磷脂酰肌醇 3 激酶 (PI3 K)/Akt、雄激素和雌激素受体以及分子靶标。此外，鼠尾草酚似乎具有良好的耐受性，因为与非致瘤细胞相比，它对癌细胞具有选择性毒性，并且当给予动物时具有良好的耐受性。这篇小型评论报告了迄今为止用鼠尾草酚进行的临床前研究，描述了作为癌症化学预防和抗癌剂的机制、功效和安全性/耐受性研究。
The Mediterranean diet and more specifically certain meats, fruits, vegetables, and olive oil found in certain parts of the Mediterranean region have been associated with a decreased cardiovascular and diabetes risk. More recently, several population based studies have observed with these lifestyle choices have reported an overall reduced risk for several cancers. One study in particular observed an inverse relationship between consumption of Mediterranean herbs such as rosemary, sage, parsley, and oregano with lung cancer. In light of these findings there is a need to explore and identify the anti-cancer properties of these medicincal herbs and to identify the phytochemicals therein. One agent in particular, carnosol, has been evaluated for anti-cancer property in prostate, breast, skin, leukemia, and colon cancer with promising results. These studies have provided evidence that carnosol targets multiple deregulated pathways associated with inflammation and cancer that include nuclear factor kappa B (NFκB), apoptotic related proteins, phosphatidylinositol-3-kinase (PI3 K)/Akt, androgen and estrogen receptors, as well as molecular targets. In addition, carnosol appears to be well tolerated in that it has a selective toxicity towards cancer cells versus non-tumorigenic cells and is well tolerated when administered to animals. This mini-review reports on the pre-clinical studies that have been performed to date with carnosol describing mechanistic, efficacy, and safety/tolerability studies as a cancer chemoprevention and anti-cancer agent.
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