Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits.
Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits.
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DOI：
10.1016/j.nutres.2009.05.001
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Erdman JW Jr
中科院分区：
文献类型：
--
作者：
King JL;Miller RJ;Blue JP Jr;O'Brien WD Jr;Erdman JW Jr
流行病学研究表明，膳食镁（Mg）摄入量和血清镁水平与动脉粥样硬化的发展呈负相关。我们假设低水平的镁会促进兔子动脉粥样硬化斑块的形成。4个月大的新西兰大白兔（n = 22）连续8周饲喂含0.12%（−Mg）、0.27%（对照）或0.43% (+Mg) Mg的致动脉粥样硬化饲粮。在基线、2、4、6和8周采集血样，检测总胆固醇、高密度脂蛋白（HDL）、非高密度脂蛋白（non-HDL）、甘油三酯（TG）、c反应蛋白、血清Mg和红细胞Mg。−Mg组的主动脉斑块明显增多，内膜厚度比对照组大42%，比+Mg组大36%。血清胆固醇水平随着时间的推移而升高，在8周时，−Mg组的总胆固醇和非hdl胆固醇和TG水平最高，+Mg组的最低，尽管这些结果没有达到显著性。随着时间的推移，血清Mg水平升高，红细胞Mg水平降低。c反应蛋白在4周和6周时显著升高，但在8周时恢复到基线水平。本研究支持了Mg摄入不足导致兔子动脉粥样硬化斑块发展增加的假设。
Epidemiological studies have shown dietary magnesium (Mg) intake and serum Mg levels to be inversely correlated with the development of atherosclerosis. We hypothesized that low levels of Mg would promote atherosclerotic plaque development in rabbits. New Zealand white rabbits (4 months old, n = 22) were fed an atherogenic diet containing 0.12% (−Mg), 0.27% (control), or 0.43% (+Mg) Mg for 8 weeks. Blood samples were obtained at baseline, 2, 4, 6, and 8 weeks and were assayed for total cholesterol, high-density lipoprotein (HDL), non-HDL, triglycerides (TG), C-reactive protein, serum Mg, and erythrocyte Mg. Aortas from −Mg had significantly more plaque, with an intima thickness 42% greater than control and 36% greater than +Mg. Serum cholesterol levels rose over time, and at 8 weeks, −Mg had the highest and +Mg the lowest total and non-HDL cholesterol and TG levels, although these results did not reach significance. Over time, serum Mg levels increased, and erythrocyte Mg levels decreased. C-reactive protein significantly increased in all groups at 4 and 6 weeks but returned to baseline levels by 8 weeks. This study supports the hypothesis that inadequate intake of Mg results in an increase in atherosclerotic plaque development in rabbits.
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