Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata.
Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata.
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三叶木通叶中两种新的五环三萜皂苷
DOI：
10.3390/molecules21070962
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发表时间：
2016-07-22
期刊：
影响因子：
--
通讯作者：
Tan JW
中科院分区：
文献类型：
--
作者：
Xu QL;Wang J;Dong LM;Zhang Q;Luo B;Jia YX;Wang HF;Tan JW
从三叶木通（Akebia trifoliata）叶中分得两个新的五环三萜皂苷，分别命名为木通苷K（Akebiaoside K，1）和木通苷N（Akebiaoside N，2）。它们都是从A.三叶草第一次通过光谱和化学方法确定了它们的结构。发现三萜5和7对人肿瘤A549、HeLa和HepG 2细胞系显示中等的体外细胞毒性，IC 50值在0.023至0.038 mM范围内。进一步揭示三萜5-7显示显著的体外α-葡萄糖苷酶抑制活性，IC 50值在0.040至0.220 mM范围内。使其比参比化合物阿卡波糖（IC 50 0.409 mM）更有效。同时，在两种生物活性测定中，未观察到分离的三萜皂苷1-4的明显抑制作用。
Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3–7. They were all isolated from the leaves of A. trifoliata for the first time. Their structures were established by spectral and chemical means. Triterpenes 5 and 7 were found to show moderate in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC50 values ranging from 0.023 to 0.038 mM. Triterpenes 5–7 were further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 values from 0.040 to 0.220 mM, making them more potent than the reference compound acarbose (IC50 0.409 mM). Meanwhile, no obvious inhibitory effects were observed for the isolated triterpene saponins 1–4 in both bioactivity assays.
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