Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study.
Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study.
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DOI：
10.1136/jnnp.2010.205757
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Pirttilä T
中科院分区：
文献类型：
--
作者：
Seppälä TT;Herukka SK;Hänninen T;Tervo S;Hallikainen M;Soininen H;Pirttilä T
单独测定血浆A-β在阿尔茨海默病(AD)的诊断中并不有用。然而，重复检测时血浆Aβ水平的变化可能有助于预测和评估早期AD或轻度认知障碍的进展。目的：探讨基线和系列血浆A-β水平与认知功能变化的关系。对2 69例患者(52例认知功能受损，2 17例对照)进行了3~6 年的临床随访。其中70例随访3 年，43例随访6 年。用双抗体夹心ELISA法测定血浆A-β水平。在随访期间认知功能下降的受试者在基线时血浆Aβ42水平较低。随访期降低者血浆Aβ42和Aβ42/Aβ40比值降低(6 年Aβ42为Aβ42 2.4 pg/ml)，而认知稳定或改善者血浆Aβ42和A 42/Aβ40比值升高。使用乙酰水杨酸、双嘧达莫、降糖或抗凝药物的受试者以及冠心病患者的Aβ40水平较高。随访期间血浆A-β-42水平降低或下降与认知功能下降有关。连续测定血浆Aβ42可能有助于检测有认知功能减退风险的受试者。
Single measurements of plasma Aβ are not useful in the diagnostics of Alzheimer's disease (AD). However, changes in plasma Aβ levels during repeated testing may be helpful in the prediction and evaluation of progression of the incipient AD or mild cognitive impairment. To examine the relation of baseline and serial plasma Aβ levels to cognitive change in follow-up. 269 subjects (52 cognitively impaired and 217 controls) from a population-based cohort were clinically followed up from 3 to 6 years. Serial plasma samples were available from 70 subjects who were followed up for 3 years and 43 subjects followed for 6 years. The plasma Aβ levels were measured using ELISA. Subjects who declined cognitively during the follow-up had lower levels of plasma Aβ42 at the baseline. Plasma Aβ42 and the Aβ42/Aβ40 ratio decreased (−2.4 pg/ml for Aβ42 in 6 years) in those who declined in follow-up, whereas Aβ42 and the Aβ42/Aβ40 ratio increased in the subjects who remained cognitively stable or improved in follow-up. Subjects using acetylsalicylic acid, dipyridamole, antidiabetic or anticoagulant drugs as well as subjects with coronary heart disease had higher levels of Aβ40. Low or decreasing plasma Aβ42 during the follow-up is associated with cognitive decline. Serial measurement of plasma Aβ42 may be useful in the detection of the subjects who are at risk for cognitive decline.
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