Reduced mediodorsal thalamic volume and prefrontal cortical spindle activity in schizophrenia.
Reduced mediodorsal thalamic volume and prefrontal cortical spindle activity in schizophrenia.
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DOI：
10.1016/j.neuroimage.2014.08.017
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发表时间：
2014-11-15
期刊：
影响因子：
5.7
通讯作者：
Ferrarelli F
中科院分区：
文献类型：
--
作者：
Buchmann A;Dentico D;Peterson MJ;Riedner BA;Sarasso S;Massimini M;Tononi G;Ferrarelli F
我们最近发现，与健康和精神对照组相比，精神分裂症患者的睡眠纺锤体明显缺陷，即非快速眼动(NREM)睡眠振荡，这种睡眠振荡在丘脑中产生，然后在皮质中放大并维持。在这里，我们调查了丘脑和大脑皮层对这些睡眠纺锤体缺陷的贡献。对精神分裂症患者和健康对照组进行了感兴趣区解剖分析(即丘脑体积)和脑电(EEG)源建模(即纺锤波相关皮层电流)。与健康对照组相比，精神分裂症患者丘脑内侧背(MD)体积减小，尤其是左侧，而整个丘脑和外侧膝状核在不同组之间没有差异。此外，左侧MD体积与额叶前区头皮记录的纺锤波数量密切相关，这些前额叶纺锤波下的皮层电流位于Brodmann区(BA)10的前额叶皮质。最后，精神分裂症患者纺锤波活动高峰时的前额叶电流显著减少，并与他们在抽象/工作记忆任务中的表现相关。总而言之，这些发现指出精神分裂症患者特定的丘脑-皮质回路存在缺陷，这与这些患者普遍报告的一些认知缺陷有关。
We recently found marked deficits in sleep spindles, non-rapid eye movement (NREM) sleep oscillations that are generated within the thalamus and then amplified and sustained in the cortex, in patients with schizophrenia compared to both healthy and psychiatric controls. Here, we investigated the thalamic and cortical contributions to these sleep spindle deficits. Anatomical Volume of Interest analysis (i.e., thalamic volumes) and electroencephalogram (EEG) source modeling (i.e., spindle-related cortical currents) were performed in patients with schizophrenia and healthy comparison subjects. Schizophrenia patients had reduced mediodorsal (MD) thalamic volumes, especially on the left side, compared to healthy controls, whereas whole thalami and lateral geniculate nuclei did not differ between groups. Furthermore, left MD volumes were strongly correlated with the number of scalp-recorded spindles in an anterior frontal region, and cortical currents underlying these anterior frontal spindles were localized in the prefrontal cortex, in Brodmann Area (BA) 10. Finally, prefrontal currents at the peak of spindle activity were significantly reduced in schizophrenia patients and correlated with their performance in an abstraction/working memory task. Altogether, these findings point to deficits in a specific thalamo-cortical circuitry in schizophrenia, which is associated with some cognitive deficits commonly reported in those patients.
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DOI：
10.1007/7854_2010_42
发表时间：
2010-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF SCHIZOPHRENIA AND ITS TREATMENT
影响因子：
--
作者：
Kalkstein, Solomon;Hurford, Irene;Gur, Ruben C.
通讯作者：
Gur, Ruben C.
影响因子：
4.5
作者：
Danos, P;Baumann, B;Bogerts, B
通讯作者：
Bogerts, B
影响因子：
--
作者：
Kemether, EM;Buchsbaum, MS;Bloom, R
通讯作者：
Bloom, R
影响因子：
5.7
作者：
Lisman J
通讯作者：
Lisman J
影响因子：
--
作者：
Ettinger, Ulrich;Picchioni, Marco;Murray, Robin M.
通讯作者：
Murray, Robin M.