Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB(1), DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health.
Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB(1), DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health.
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DOI：
10.3390/toxins13020156
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发表时间：
2021-02-17
期刊：
影响因子：
4.2
通讯作者：
Sun LH
中科院分区：
文献类型：
--
作者：
Zhao L;Feng Y;Wei JT;Zhu MX;Zhang L;Zhang JC;Karrow NA;Han YM;Wu YY;Guo YM;Sun LH
本研究旨在评价霉菌毒素粘合剂对降低日粮中黄曲霉毒素B1(AFB1)、脱氧雪腐镰刀菌烯醇(DON)和赭曲霉毒素A(OTA)共存对蛋鸡的不良影响的效果。选用26周龄罗曼蛋鸡360只，随机分为4组，每组10个重复，每个重复9只鸡。4组分别给予基础饲料(BD；对照组)、BD+0.15 mg/kg AFB1+1.5 mg/kg DON+0.12 mg/kg OTA(毒素)、BD+毒素+Toxo-HP粘合剂(毒素+HP)、BD+毒素+TOXO XL粘合剂(毒素+XL)，共12周。与对照组相比，日粮中添加真菌毒素降低了蛋鸡的总采食量、总蛋重和产蛋率(P<；0.10)，但提高了料蛋比(2.5-6.1%)和死亡率。添加TOXO HP和XL粘合剂(P<；0.10)可减轻真菌毒素引起的这些改变。此外，饲粮真菌毒素使蛋壳强度降低12.3%，12周龄时蛋壳中DON的积累量为249μg/kg，而添加TOXO HP或XL可缓解DON引起的蛋壳强度变化，阻止DON在鸡蛋中的积累(P<；0.05)。此外，日粮真菌毒素增加了仔猪肝脏的相对重量，但降低了脾和腺胃的相对重量11.6-22.4%(P<；0.05)。霉菌毒素暴露还增加了丙氨酸氨基转移酶的活性，降低了血清免疫球蛋白(Ig)A、Ig M和Ig G浓度9.2-26.1%(P<；0.05)。此外，霉菌毒素暴露还导致组织病理学损伤，十二指肠、空肠和(或)回肠的绒毛高度、绒毛高度/隐窝深度和隐窝深度降低(P<；0.05)。值得注意的是，大多数这些组织学变化通过补充TOXO HP和XL得到缓解(P<；0.05)。综上所述，本研究表明，霉菌毒素粘合剂TOXO HP和XL可以帮助缓解黄曲霉毒素1、DON和OTA对蛋鸡生产性能、鸡蛋品质和健康的联合影响。
The objective of this study was to evaluate the efficacy of mycotoxin binders in reducing the adverse effects of co-occurring dietary aflatoxin B1 (AFB1), deoxynivalenol (DON) and ochratoxin A (OTA) on laying hens. Three hundred and sixty 26-week-old Roman laying hens were randomly allocated into four experimental groups with 10 replicates of nine birds each. The four groups received either a basal diet (BD; Control), a BD supplemented with 0.15 mg/kg AFB1 + 1.5 mg/kg DON + 0.12 mg/kg OTA (Toxins), a BD + Toxins with Toxo-HP binder (Toxins + HP), or a BD + Toxins with TOXO XL binder (Toxins + XL) for 12 weeks. Compared to the control, dietary supplementation of mycotoxins decreased (P < 0.10) total feed intake, total egg weight, and egg-laying rate, but increased feed/egg ratio by 2.5–6.1% and mortality during various experimental periods. These alterations induced by mycotoxins were alleviated by supplementation with both TOXO HP and XL binders (P < 0.10). Furthermore, dietary mycotoxins reduced (P < 0.05) eggshell strength by 12.3% and caused an accumulation of 249 μg/kg of DON in eggs at week 12, while dietary supplementation with TOXO HP or XL mitigated DON-induced changes on eggshell strength and prevented accumulation of DON in eggs (P < 0.05). Moreover, dietary mycotoxins increased relative liver weight, but decreased spleen and proventriculus relative weights by 11.6–22.4% (P < 0.05). Mycotoxin exposure also increased alanine aminotransferase activity and reduced immunoglobulin (Ig) A, IgM, and IgG concentrations in serum by 9.2–26.1% (P < 0.05). Additionally, mycotoxin exposure induced histopathological damage and reduced villus height, villus height/crypt depth, and crypt depth in duodenum, jejunum and (or) ileum (P < 0.05). Notably, most of these histological changes were mitigated by supplementation with both TOXO HP and XL (P < 0.05). In conclusion, the present study demonstrated that the mycotoxin binders TOXO HP and XL can help to mitigate the combined effects of AFB1, DON, and OTA on laying hen performance, egg quality, and health.
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影响因子：
4.2
作者：
Bertero A;Moretti A;Spicer LJ;Caloni F
通讯作者：
Caloni F
影响因子：
4.4
作者：
Li, Z.;Yang, Z. B.;Wu, Y. B.
通讯作者：
Wu, Y. B.
DOI：
10.1080/02652038809373708
发表时间：
1988-07-01
影响因子：
2.9
作者：
MICCO, C;MIRAGLIA, M;STASOLLA, D
通讯作者：
STASOLLA, D
影响因子：
--
作者：
Liu J;Sun L;Zhang N;Zhang J;Guo J;Li C;Rajput SA;Qi D
通讯作者：
Qi D
影响因子：
4.3
作者：
Jia, Ru;Ma, Qiugang;Zhao, Lihong
通讯作者：
Zhao, Lihong