Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge.
Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge.
复制标题
DOI：
10.1016/j.neuroscience.2010.06.052
复制
发表时间：
2010-09-29
期刊：
影响因子：
3.3
通讯作者：
Spencer, R. L.
中科院分区：
文献类型：
--
作者：
Weinberg, M. S.;Grissom, N.;Paul, E.;Bhatnagar, S.;Maier, S. F.;Spencer, R. L.
控制一个厌恶的经历可以极大地影响生物体对随后的压力源的反应。我们比较了逃避（ES）和轭不可避免（IS）电尾电击对下丘脑-垂体-肾上腺（HPA）轴激素（皮质酮和ACTH），神经（c-fos mRNA）和行为（挣扎）的影响，随后的限制。我们发现，虽然HPA轴的反应，在限制的两个先前强调组高于压力幼稚大鼠和彼此没有不同，缺乏控制的尾电击的经验导致增加限制引起的挣扎行为的IS大鼠相比，压力幼稚和ES大鼠。此外，IS组基底外侧杏仁核c-fos表达选择性增加，且基底外侧杏仁核c-fos mRNA表达与挣扎行为呈正相关。内侧前额叶皮层是调节ES和IS的一些不同神经化学和行为效应的关键大脑区域，在ES和IS组中，限制诱导的c-fos表达惊人地相似，低于压力幼稚大鼠，并且与挣扎行为无关。我们的研究结果表明，基底外侧杏仁核的活动可能与ES和IS对随后的行为反应约束的差异性影响，而不会导致并发HPA轴激素反应。
Control over an aversive experience can greatly impact the organism’s response to subsequent stressors. We compared the effects of escapable (ES) and yoked inescapable (IS) electric tail shocks on the hypothalamic-pituitary-adrenal (HPA) axis hormonal (corticosterone and ACTH), neural (c-fos mRNA) and behavioral (struggling) response to subsequent restraint. We found that although the HPA axis response during restraint of both previously stressed groups were higher than stress-naïve rats and not different from each other, lack of control over the tailshock experience led to an increase in restraint-induced struggling behavior of the IS rats compared to both stress-naïve and ES rats. Additionally, c-fos expression in the basolateral amygdala was increased selectively in the IS group, and relative c-fos mRNA expression in the basolateral amygdala positively correlated with struggling behavior. Restraint-induced c-fos expression in the medial prefrontal cortex, a brain area critical for mediating some of the differential neurochemical and behavioral effects of ES and IS, was surprisingly similar in both ES and IS groups, lower than that of stress-naïve rats, and did not correlate with struggling behavior. Our findings indicate that basolateral amygdala activity may be connected with the differential effects of ES and IS on subsequent behavioral responses to restraint, without contributing to the concurrent HPA axis hormone response.
登录
查看更多内容
影响因子：
2.7
作者：
Grissom, Nicola;Kerr, Wesley;Bhatnagar, Seema
通讯作者：
Bhatnagar, Seema
影响因子：
3.5
作者：
Agrati, D.;Zuluaga, M. J.;Ferreira, A.
通讯作者：
Ferreira, A.
影响因子：
2.9
作者：
McIntyre, DC;Kent, P;Anisman, H
通讯作者：
Anisman, H
影响因子：
2.9
作者：
Merali, Z;Kent, P;Anisman, H
通讯作者：
Anisman, H
影响因子：
3.3
作者：
Girotti, M;Pace, TWW;Spencer, RL
通讯作者：
Spencer, RL