Parity, early menopause and the incidence of bladder cancer in women: a case-control study and meta-analysis.
Parity, early menopause and the incidence of bladder cancer in women: a case-control study and meta-analysis.
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DOI：
10.1016/j.ejca.2010.10.007
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发表时间：
2011-03
影响因子：
8.4
通讯作者：
Karagas, M. R.
中科院分区：
文献类型：
--
作者：
Dietrich, K.;Demidenko, E.;Schned, A.;Zens, M. S.;Heaney, J.;Karagas, M. R.
男性膀胱癌的发病率明显高于女性。虽然有证据表明生殖和激素风险因素可能会影响膀胱癌的风险，但数据尚无定论。我们在美国新罕布什尔州 (NH) 进行的基于人群的膀胱癌病例对照研究中检查了生殖、月经和激素使用史（n=207 名女性病例和 n=463 名女性对照）。此外，我们对已发表的文献进行了荟萃分析。我们使用无条件逻辑回归分析来计算 NH 研究中与每个风险因素相关的调整优势比。我们使用逆方差效应模型将这些估计与已发表文献中的估计相结合。在 NH 研究中，发现与未生育过的女性相比，曾经生育过的女性的优势比略有下降，而接受手术绝经（双侧卵巢切除术）的女性的优势比则升高，尤其是在年轻时。没有发现与口服避孕药的使用或激素替代疗法有总体关联。这些发现与荟萃分析结果基本一致，即曾经生育过的女性的综合 RR 估计值降低（曾经生育过的与未生育过的组合 RR 估计值=0.66，95%CI 0.55-0.79），而早期绝经的女性则升高（早期与晚期绝经的组合 RR 估计值=1.59，95%CI 1.31-1.92）。其他因素没有观察到一致的风险。一些生殖和月经因素似乎与女性膀胱癌的发病率有关；但影响是否是由女性荷尔蒙引起的尚不确定。
Incidence rates of bladder cancer are notably higher in men than women. While there is evidence that reproductive and hormonal risk factors may influence risk of bladder cancer, data are inconclusive. We examined reproductive, menstrual and hormonal use history in our population-based case-control study of bladder cancer in New Hampshire (NH), USA (n=207 women cases and n=463 women controls). Additionally, we performed a meta-analysis of the published literature. We used unconditional logistic regression analysis to compute adjusted odds ratios associated with each risk factor in the NH study. We combined these estimates with those from the published literature using inverse variance effects models. In the NH study, a slightly decreased odds ratio was found among women who had ever had a birth compared to nulliparous women and an elevated odds ratio among women who underwent surgical menopause (bilateral oophorectomy), especially at an early age. No overall associations were found with oral contraceptive use or hormone replacement therapy. These findings were generally in agreement with the meta-analytic results for which the combined RR estimate was reduced among ever parous women (combined RR estimate for ever parous versus nulliparous =0.66, 95%CI 0.55-0.79) and elevated among those undergoing an early menopause (combined RR estimate for early versus late menopause =1.59, 95%CI 1.31–1.92). No consistent risk was observed for the other factors. Some reproductive and menstrual factors appear to be related to the incidence of bladder cancer among women; but whether effects are due to female hormones is uncertain.
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影响因子：
6.2
作者：
Scosyrev, Emil;Noyes, Katia;Messing, Edward
通讯作者：
Messing, Edward
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.5
作者：
Blakeman, PJ;Hilton, P;Bulmer, JN
通讯作者：
Bulmer, JN
影响因子：
2.3
作者：
CANTOR, KP;LYNCH, CF;JOHNSON, D
通讯作者：
JOHNSON, D
影响因子：
5.1
作者：
Pelucchi, C;La Vecchia, C;Franceschi, S
通讯作者：
Franceschi, S