Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life
Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life
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早期社会不稳定会影响青春期期间的血浆睾酮，但不会改变生殖能力或晚年的压力测量
DOI：
10.1016/j.physbeh.2013.08.008
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发表时间：
2013
影响因子：
2.9
通讯作者：
Kaiser
中科院分区：
文献类型：
--
作者：
Siegeler;Wistuba;von Engelhardt;Sachser;Kaiser
社会环境在调节各种群体生活物种中动物的激素和行为特征的过程中起着重要作用。例如，在野生猕猴中，怀孕和哺乳期间不稳定的社会环境条件导致雄性后代的生物行为特征不稳定。本研究探讨了妊娠期和哺乳期社会环境对雄性豚鼠子代血浆睾酮发育、生殖能力和应激系统活性的影响。为此目的，12个儿子的母亲生活在一个不稳定的社会环境在怀孕和哺乳期进行了比较，12个儿子的母亲生活在一个稳定的社会环境在同一时间。从20日龄至107日龄测定血浆睾酮（T）和血浆皮质醇（C）浓度。肾上腺酪氨酸羟化酶（TH）的活性和不同参数的生殖能力（睾丸，附睾和附属性腺的重量，睾丸的细胞组成，DNA片段化指数和精子活力参数）进行了分析，在107天的年龄。TH活性和血浆C不受生命早期不同社会环境条件的影响。然而，T浓度的发展时间过程是显着不同的：儿子的母亲在怀孕和哺乳期间生活在一个不稳定的社会环境中显示出延迟增加的T浓度在青春期左右相比，控制。相比之下，在本研究中测量的生殖相关参数在两组之间没有显著差异。因此，早期的社会不稳定影响血浆睾酮的发展在青春期的一个显着的方式，但不会改变生殖能力或措施的压力在以后的生活。
The social environment plays an important role in modulating processes of the hormonal and behavioural profile of an animal in a variety of group-living species. In wild cavies for instance, unstable social environmental conditions during pregnancy and lactation lead to an infantilised biobehavioural profile of the male offspring. In the present study, the influence of the social environment during pregnancy and lactation on the male wild cavy offsprings' plasma testosterone development, reproductive capacity and stress system activity was investigated. To this purpose, 12 sons whose mothers had lived in an unstable social environment during pregnancy and lactation were compared with 12 sons whose mothers had lived in a stable social environment during the same time. Plasma testosterone (T) and plasma cortisol (C) concentrations were determined from days 20 to 107 of age. Adrenal tyrosine hydroxylase (TH) activity and different parameters of reproductive capacity (weights of testes, epididymides and accessory sex glands, cellular composition of the testes, DNA fragmentation indices and sperm motility parameters) were analysed at day 107 of age. TH activity and plasma C were unaffected by different social environmental conditions early in life. The developmental time course of T concentrations, however, was significantly different: Sons whose mothers had lived in an unstable social environment during pregnancy and lactation showed a delayed increase in T concentrations around adolescence compared to controls. In contrast, no reproduction-related parameters measured within this study differed significantly between the two groups. Thus, early social instability affects plasma testosterone development during adolescence in a significant way but does not alter reproductive capacity or measures of stress later in life.
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影响因子：
3.8
作者：
J. Wistuba;C. Luetjens;J. Ehmcke;K. Redmann;O. S. Damm;A. Steinhoff;R. Sandhowe;E. Nieschlag;M. Simoni;S. Schlatt
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DOI：
--
发表时间：
1976
期刊：
Journal of Reproduction and Fertility
影响因子：
--
作者：
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通讯作者：
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DOI：
--
发表时间：
1995
期刊：
影响因子：
--
作者：
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通讯作者：
A. Lawrence
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影响因子：
2.5
作者：
C. Yeung;G. Oberländer;T. Cooper
通讯作者：
T. Cooper
一种快速、简单的酪氨酸羟化酶活性放射测定法。
影响因子：
2.9
作者：
T. Nagatsu;M. Levitt;S. Udenfriend
通讯作者：
S. Udenfriend