Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission.
Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission.
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DOI：
10.1016/j.pscychresns.2011.11.004
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发表时间：
2012-04-30
影响因子：
2.3
通讯作者：
Blumberg, Hilary P.
中科院分区：
文献类型：
--
作者：
Kerestes, Rebecca;Bhagwagar, Zubin;Nathan, Pradeep J.;Meda, Shashwath A.;Ladouceur, Cecile D.;Maloney, Kathleen;Matuskey, David;Ruf, Barbara;Saricicek, Aybala;Wang, Fei;Pearlson, Godfrey D.;Phillips, Mary L.;Blumberg, Hilary P.
急性抑郁症患者的眶额皮层（OFC）和背外侧前额叶皮层（DLPFC）对负性情绪刺激的反应异常。然而，在未用药的重度抑郁症缓解期（rMDD）患者中进行的研究很少，以评估这些是否是特质异常。为了解决这个问题，19名无药物治疗的rMDD个体和20名健康对照（HC）参与者使用功能性磁共振成像进行扫描，同时执行内隐情绪处理任务，其中他们标记描绘负面（恐惧），积极（快乐）和中性面部表情的面部性别。使用感兴趣区域方法比较rMDD组和HC组的两个对比：恐惧与中性和快乐与中性。相对于HC，rMDD表现出减少激活左眶额皮层和DLPFC恐惧（与中立）的面孔。在rMDD组中，右侧DLPFC对恐惧（与中性）面孔的激活与正常心境的持续时间呈显著正相关。研究结果支持赤字左OFC和DLPFC反应的负面情绪刺激，在情感正常的MDD期间，这可能反映了疾病的特征标记或“疤痕”，由于以前的抑郁症。恢复也可能与右侧DLPFC功能的代偿性增加有关。
Abnormalities in the response of the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) to negative emotional stimuli have been reported in acutely depressed patients. However, there is a paucity of studies conducted in unmedicated individuals with major depressive disorder in remission (rMDD) to assess whether these are trait abnormalities. To address this issue, 19 medication-free rMDD individuals and 20 healthy comparison (HC) participants were scanned using functional magnetic resonance imaging while performing an implicit emotion processing task in which they labeled the gender of faces depicting negative (fearful), positive (happy) and neutral facial expressions. The rMDD and HC groups were compared using a region-of-interest approach for two contrasts: fear vs. neutral and happy vs. neutral. Relative to HC, rMDD showed reduced activation in left OFC and DLPFC to fearful (vs. neutral) faces. Right DLPFC activation to fearful (vs. neutral) faces in the rMDD group showed a significant positive correlation with duration of euthymia. The findings support deficits in left OFC and DLPFC responses to negative emotional stimuli during euthymic periods of MDD, which may reflect trait markers of the illness or a ‘scar’ due to previous depression. Recovery may also be associated with compensatory increases in right DLPFC functioning.
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影响因子：
11.3
作者：
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通讯作者：
KRAEMER, HC
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作者：
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