Changes of Peripapillary Retinal Nerve Fiber Layer in Childhood Glaucoma: A Systematic Review and Meta-Analysis.
Changes of Peripapillary Retinal Nerve Fiber Layer in Childhood Glaucoma: A Systematic Review and Meta-Analysis.
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儿童青光眼视乳头周围视网膜神经纤维层的变化：系统评价和荟萃分析
DOI：
10.3389/fmed.2021.740152
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zhuo Y
中科院分区：
文献类型：
--
作者：
Wen Y;Zhu Y;Zhuo Y
目的：大量关于儿童青光眼改变和异常的研究已检测到视网膜神经纤维层 (RNFL) 厚度，但这些研究得出的有关 RNFL 变薄区域的结果不一致。对儿科患者 RNFL 特征的研究将有助于深入了解儿童青光眼的神经病理机制。因此，不同象限的细化程度值得进一步讨论和探索。方法：使用 Cochrane 对照试验中央注册库、Medline、Embase 和 PubMed 数据库进行系统文献检索，以识别从开始到 2021 年 4 月 1 日发表的临床研究。结果：本综述纳入 10 项研究，总共 311 名青光眼儿童和 444 名非青光眼对照儿童。结果显示，青光眼儿科患者的平均视乳头周围 RNFL (pRNFL) 厚度减弱 [加权平均差 (WMD) = -20.75； 95% CI -27.49 至 -14.01； p < 0.00001]。此外，青光眼儿科组中八个象限（上、下、颞、鼻、颞上、颞下、鼻上和鼻下）的 pRNFL 厚度有不同程度的减少。结论：本研究表明，儿童青光眼患者的 8 个 RNFL 厚度区域出现不同程度的变薄。然而，由于明显的异质性，在解释结果时需要谨慎。未来的研究，尤其是更大样本和多中心的研究，需要证实我们的结果。
Objectives: Retinal nerve fiber layer (RNFL) thickness has been detected by numerous studies about alterations and abnormalities in childhood glaucoma, but these studies have yielded inconsistent results about the RNFL thinning region. The investigation of characteristics of RNFL in pediatric patients would contribute to the deep understanding of the neuropathic mechanisms of childhood glaucoma. Thus, the degree of thinning in different quadrants deserves further discussion and exploration. Method: A systematic literature search was conducted using the Cochrane Central Register of Controlled Trials, Medline, Embase, and PubMed databases to identify clinical studies published from inception to April 1, 2021. Results: Ten studies were included in this review with a total of 311 children with glaucoma and 444 in nonglaucomatous controls. The results revealed that average peripapillary RNFL (pRNFL) thickness was attenuated in pediatric patients with glaucoma [weighted mean difference (WMD) = −20.75; 95% CI −27.49 to −14.01; p < 0.00001]. Additionally, pRNFL thickness in eight quadrants (superior, inferior, temporal, nasal, superotemporal, inferotemporal, superonasal, and inferonasal) had different levels of reduction in the pediatric group of glaucoma. Conclusion: This study indicates that eight regions of RNFL thickness show various degrees of thinning in childhood glaucoma. However, caution is required in the interpretation of results due to marked heterogeneity. Future studies, especially larger samples and multicenter, need to confirm our results.
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影响因子：
13.7
作者：
Dahlmann-Noor, Annegret;Tailor, Vijay;Papadopoulos, Maria
通讯作者：
Papadopoulos, Maria
影响因子：
--
作者：
El-Dairi, Mays A.;Asrani, Sanjay G.;Freedman, Sharon F.
通讯作者：
Freedman, Sharon F.
影响因子：
4.1
作者：
Ghasia, Fatema F.;Freedman, Sharon F.;El-dairi, Mays
通讯作者：
El-dairi, Mays
影响因子：
13.7
作者：
Ben-Zion, Itay;Tomkins, Oren;Helveston, Eugene M.
通讯作者：
Helveston, Eugene M.
影响因子：
3.7
作者：
Kansal V;Armstrong JJ;Pintwala R;Hutnik C
通讯作者：
Hutnik C