The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.
The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.
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补充维生素E对成人选定炎症生物标志物的影响：随机临床试验的系统综述和荟萃分析
DOI：
10.1038/s41598-020-73741-6
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发表时间：
2020-10-14
影响因子：
4.6
通讯作者：
Sadeghi O
中科院分区：
文献类型：
--
作者：
Asbaghi O;Sadeghian M;Nazarian B;Sarreshtedari M;Mozaffari-Khosravi H;Maleki V;Alizadeh M;Shokri A;Sadeghi O
The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the effects of vitamin E supplementation on inflammatory biomarkers in adults. We searched the online databases using relevant keywords up to November 2019. Randomized clinical trials (RCTs) investigating the effect of vitamin E, compared with the placebo, on serum concentrations of inflammatory cytokines were included. Overall, we included 33 trials with a total sample size of 2102 individuals, aged from 20 to 70 years. Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (− 0.52, 95% CI − 0.80, − 0.23 mg/L, P < 0.001). Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used α-tocopherol and those trials that included patients with disorders related to insulin resistance. Moreover, we found a significant reducing effect of vitamin E supplementation on tumor necrosis factor-α (TNF-α) concentrations at high dosages of vitamin E; such that based on dose–response analysis, serum TNF-α concentrations were reduced significantly at the dosages of ≥ 700 mg/day vitamin E (Pnon-linearity = 0.001). Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults. Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting.
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影响因子：
2.9
作者：
Aryaeian N;Shahram F;Djalali M;Eshragian MR;Djazayeri A;Sarrafnejad A;Naderi N;Chamari M;Fatehi F;Zarei M
通讯作者：
Zarei M
影响因子：
2.7
作者：
Berry, Donold;Wathen, J. Kyle;Newell, Margaret
通讯作者：
Newell, Margaret
影响因子：
4.6
作者：
Ekhlasi G;Zarrati M;Agah S;Hosseini AF;Hosseini S;Shidfar S;Soltani Aarbshahi SS;Razmpoosh E;Shidfar F
通讯作者：
Shidfar F
影响因子：
3.6
作者：
Dalgard, Christine;Nielsen, Flemming;de Maat, Moniek P. M.
通讯作者：
de Maat, Moniek P. M.
影响因子：
2.9
作者：
Daud, Zulfitri A. Mat;Tubie, Boniface;Khosla, Pramod
通讯作者：
Khosla, Pramod