Change in the Lipid Transport Capacity of the Liver and Blood during Reproduction in Rats.
Change in the Lipid Transport Capacity of the Liver and Blood during Reproduction in Rats.
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DOI：
10.3389/fphys.2017.00517
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发表时间：
2017
影响因子：
4
通讯作者：
Hood WR
中科院分区：
文献类型：
--
作者：
Zhang Y;Kallenberg C;Hyatt HW;Kavazis AN;Hood WR
为了支持繁殖的高能量需求，雌性哺乳动物在许多生理过程中表现出可塑性，例如脂质运输系统。脂质在生殖过程中支持雌性的能量需求，并在哺乳期通过子宫内的胎盘或乳汁支持发育中的后代的能量和结构需求。我们假设，支持生殖女性脂质运输的关键蛋白质会在怀孕和哺乳期间增加，但在生殖结束后不久就会下降到非生殖水平。我们比较了怀孕后期生殖Sprague-Dawley大鼠的肝脏中肝型胞质脂肪酸转运蛋白（L-FABPc）、质膜脂肪酸转运蛋白（FABPpm）、脂肪酸转位酶（FAT/CD36）的相对蛋白水平（脂质储存和合成的关键部位）以及血清中游离脂肪酸转运蛋白白蛋白和甘油三酯转运蛋白[以载脂蛋白B（apoB）为代表]的水平。哺乳高峰期、哺乳后 1 周以及非生殖大鼠。我们发现，与非生育大鼠相比，怀孕大鼠的所有脂质转运蛋白水平更高。哺乳期大鼠的 FAT/CD36 和 FABPpm 水平也高于非生育期大鼠。此外，除 FAT/CD36 外，所有脂肪转运蛋白在哺乳后也会回落至非生殖水平。这些结果表明，在妊娠后期和哺乳期，肝细胞的脂肪摄取和运输能力升高。肝脏脂质分泌在妊娠期间上调，但在哺乳期间不会上调。这些数据支持生殖阶段肝脏和血液中脂质转运能力的可塑性。
To support the high energetic demands of reproduction, female mammals display plasticity in many physiological processes, such as the lipid transport system. Lipids support the energy demands of females during reproduction, and energy and structural demands of the developing offspring via the placenta in utero or milk during the suckling period. We hypothesized that key proteins supporting lipid transport in reproductive females will increase during pregnancy and lactation, but drop to non-reproductive levels shortly after reproduction has ended. We compared the relative protein levels of liver-type cytosolic fatty acid transporter (L-FABPc), plasma membrane fatty acid transporter (FABPpm), fatty acid translocase (FAT/CD36) in the liver, a key site of lipid storage and synthesis, and free fatty acid transporter albumin and triglyceride transporter [represented by apolipoprotein B (apoB)] levels in serum in reproductive Sprague-Dawley rats during late pregnancy, peak-lactation, and 1-week post-lactation as well as in non-reproductive rats. We found that all lipid transporter levels were greater in pregnant rats compared to non-reproductive rats. Lactating rats also showed higher levels of FAT/CD36 and FABPpm than non-reproductive rats. Moreover, all fat transporters also dropped back to non-reproductive levels during post-lactation except for FAT/CD36. These results indicate that fat uptake and transport capacities in liver cells are elevated during late gestation and lactation. Liver lipid secretion is up-regulated during gestation but not during lactation. These data supported the plasticity of lipid transport capacities in liver and blood during reproductive stages.
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DOI：
10.1016/j.jnutbio.2010.01.005
发表时间：
2010-11
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Atshaves BP;Martin GG;Hostetler HA;McIntosh AL;Kier AB;Schroeder F
通讯作者：
Schroeder F
影响因子：
3.5
作者：
Gutgesell, Anke;Ringseis, Robert;Eder, Klaus
通讯作者：
Eder, Klaus
DOI：
10.1016/0005-2760(95)00114-r
发表时间：
1995-09-14
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM
影响因子：
--
作者：
BESNARD, P;FOUCAUD, L;CARLIER, H
通讯作者：
CARLIER, H
DOI：
10.4137/grsb.s12005
发表时间：
2013
期刊：
Gene regulation and systems biology
影响因子：
--
作者：
Akbar H;Schmitt E;Ballou MA;Corrêa MN;Depeters EJ;Loor JJ
通讯作者：
Loor JJ
影响因子：
5.6
作者：
Brett KE;Ferraro ZM;Yockell-Lelievre J;Gruslin A;Adamo KB
通讯作者：
Adamo KB