Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts.
Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts.
复制标题
慢性疼痛中的音乐幻觉：前扣带回皮质调节内部产生的感知。
DOI：
10.3389/fneur.2021.669172
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发表时间：
2021
影响因子：
3.4
通讯作者：
Shirvalkar P
中科院分区：
文献类型：
--
作者：
Schmitgen A;Saal J;Sankaran N;Desai M;Joseph I;Starr P;Chang EF;Shirvalkar P
前扣带皮层（ACC）已被广泛牵连的功能性脑网络的慢性疼痛。ACC的电刺激已被提议作为难治性慢性疼痛的治疗，尽管治疗作用的机制仍不清楚。据报道，刺激ACC会产生许多不同的行为和感知反应，该区域可能在感觉和情感整合以及调节内部产生的感知状态中发挥各种作用。在这个病例系列中，我们报告了两名难治性慢性疼痛患者在电刺激ACC后出现的主观音乐幻觉（MH）。在一个N-of-1的分析，从一个病人，我们确定了神经活动（局部场电位）区分MH从非MH的条件，并在一个任务，包括音乐听。音乐幻觉与ACC中α波段活动减少和γ波段活动增加有关。听类似的音乐与ACC α和γ功率的不同变化有关，扩展先前的结果，内部产生的知觉现象是由ACC中的电路支持的。我们讨论了这些发现的背景下，幻影知觉现象和慢性疼痛可能被解释为一个持久性内部生成的受体。
The anterior cingulate cortex (ACC) has been extensively implicated in the functional brain network underlying chronic pain. Electrical stimulation of the ACC has been proposed as a therapy for refractory chronic pain, although, mechanisms of therapeutic action are still unclear. As stimulation of the ACC has been reported to produce many different behavioral and perceptual responses, this region likely plays a varied role in sensory and emotional integration as well as modulating internally generated perceptual states. In this case series, we report the emergence of subjective musical hallucinations (MH) after electrical stimulation of the ACC in two patients with refractory chronic pain. In an N-of-1 analysis from one patient, we identified neural activity (local field potentials) that distinguish MH from both the non-MH condition and during a task involving music listening. Music hallucinations were associated with reduced alpha band activity and increased gamma band activity in the ACC. Listening to similar music was associated with different changes in ACC alpha and gamma power, extending prior results that internally generated perceptual phenomena are supported by circuits in the ACC. We discuss these findings in the context of phantom perceptual phenomena and posit a framework whereby chronic pain may be interpreted as a persistent internally generated percept.
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影响因子：
6.6
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
通讯作者：
Jardri R
DOI：
10.1073/pnas.1018466108
发表时间：
2011-05-17
影响因子：
11.1
作者：
De Ridder, Dirk;Elgoyhen, Ana Belen;Langguth, Berthold
通讯作者：
Langguth, Berthold
影响因子：
3.2
作者：
Adams R;David AS
通讯作者：
David AS
影响因子：
4.8
作者：
Boccard, Sandra G. J.;Fitzgerald, James J.;Aziz, Tipu Z.
通讯作者：
Aziz, Tipu Z.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y