CD133+ cancer stem-like cells promote migration and invasion of salivary adenoid cystic carcinoma by inducing vasculogenic mimicry formation.
CD133+ cancer stem-like cells promote migration and invasion of salivary adenoid cystic carcinoma by inducing vasculogenic mimicry formation.
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CD133( )癌症干细胞样细胞通过诱导血管生成拟态形成促进唾液腺腺样囊性癌的迁移和侵袭
DOI：
10.18632/oncotarget.8665
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发表时间：
2016-05-17
期刊：
影响因子：
--
通讯作者：
Liang XH
中科院分区：
文献类型：
--
作者：
Wang SS;Gao XL;Liu X;Gao SY;Fan YL;Jiang YP;Ma XR;Jiang J;Feng H;Chen QM;Tang YJ;Tang YL;Liang XH
肿瘤干细胞（cancer stem cells，CSCs）因其在多种肿瘤侵袭和转移中的作用而受到广泛关注。在此，我们发现干细胞标记物CD 133的阳性表达与涎腺腺样囊性癌（ACC）标本中血管生成拟态（VM）形成、局部区域复发、远处转移和预后不良呈正相关。与CD 133 − ACC细胞相比，CD 133+癌症干细胞样细胞具有更强的迁移和侵袭能力，以及更多的VM形成。注射CD 133+细胞的裸鼠的CD 133+癌干细胞样细胞和异种移植瘤中内皮细胞标志物VE-钙粘蛋白、MMP-2和MMP-9的表达水平显著高于注射CD 133 −细胞的裸鼠。提示CD 133+肿瘤干细胞样细胞可能通过诱导VM的形成促进ACC的迁移和侵袭。
Cancer stem cells (CSCs) have gained much attention due to their roles in the invasion and metastasis of numerous kinds of human cancers. Here, we showed that the positive expression of CD133, the stemness marker, was positively associated with vasculogenic mimicry (VM) formation, local regional recurrence, distant metastasis and poorer prognosis in salivary adenoid cystic carcinoma (ACC) specimens. Compared with CD133− ACC cells, CD133+ cancer stem-like cells had more migration and invasion capabilities, as well as more VM formation. The levels of endothelial cell marker VE-cadherin, MMP-2 and MMP-9 expression in CD133+ cancer stem-like cells and xenograft tumors of nude mice injected with CD133+ cells were significantly higher than those with CD133− cells. The data indicated that CD133+ cancer stem-like cells might contribute to the migration and invasion of ACC through inducing VM formation.
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唾液腺腺样囊性癌转录因子Snail1表达与预后的相关性
DOI：
10.1016/j.tripleo.2010.06.015
发表时间：
2010-12-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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